Self-control study of multi-omics in identification of microenvironment characteristics in calcium oxalate kidney stones

Xu, Shang; Liu, Zhi-Long; Zhang, Tian-Wei; Li, Bin; Cao, Yuan-Chao; Wang, Xin-Ning; Jiao, Wei

doi:10.1186/s12882-025-04026-1

Table 2 List of deps in the urine of bilateral renal pelvis in patients with unilateral kidney stones

From: Self-control study of multi-omics in identification of microenvironment characteristics in calcium oxalate kidney stones

Protein name	Abbreviation	Accession	Mean FC	P-value	Function	Expression
Neutrophil defensin 1	DEFA1B	P59665	97.85	0.012	Antibiotic	Up
Galectin-10	CLC	Q05315	61.58	0.012	Lectin	Up
Eosinophil cationic protein	RNASE3	P12724	54.25	0.012	Antibiotic	Up
Protein S100-A9	S100A9	P06702	37.71	0.012	Antimicrobial, Antioxidant	Up
Protein S100-A8	S100A8	P05109	30.64	0.028	Antimicrobial	Up
Coronin-1 A	CORO1A	P31146	29.73	0.038	Actin-binding	Up
Histone H1.5	H1-5	P16401	26.51	0.009	Receptor, Transducer	Up
Apolipoprotein B-100	APOB	P04114	23.70	0.018	Heparin-binding	Up
C4b-binding protein alpha chain	C4BPA	P04003	23.38	0.016	complement activation	Up
Integrin beta-2	ITGB2	P05107	17.31	0.026	Integrin, Receptor	Up
Neutrophil defensin 3	DEFA3	P59666	16.56	0.012	Antibiotic	Up
Plastin-2	LCP1	P13796	15.75	0.004	DNA-binding	Up
Fibrinogen beta chain	FGB	P02675	14.68	0.043	Blood coagulation	Up
Ras-related C3 botulinum toxin substrate 2	RAC2	P15153	14.48	0.041	Ligand	Up
Immunoglobulin heavy constant gamma 1	IGHG1	P01857	13.34	0.044	Adaptive immunity	Up
Apolipoprotein A-I	APOA1	P02647	13.28	0.032	Lipid metabolism	Up
Fascin	FSCN1	Q16658	13.06	0.012	Actin-binding	Up
Fibrinogen gamma chain	FGG	P02679	12.08	0.041	Blood coagulation	Up
Lamin-B1	LMNB1	P20700	12.05	0.030	Intermediate filament	Up
Apolipoprotein A-II	APOA2	P02652	11.64	0.030	Lipid transport	Up
Complement factor H	CFH	P08603	11.51	0.014	Complement alternate pathway	Up
Coagulation factor XIII B chain	F13B	P05160	10.98	0.045	Blood coagulation	Up
Phosphatidylinositol-glycan-specific phospholipase D	GPLD1	P80108	10.84	0.014	Hydrolase	Up
Histidine-rich glycoprotein	HRG	P04196	9.60	0.017	Heparin-binding	Up
Complement component C8 alpha chain	C8A	P07357	8.01	0.011	Translocase	Up
Fibrinogen alpha chain	FGA	P02671	7.35	0.012	Blood coagulation	Up
High mobility group protein B2	HMGB2	P26583	6.19	0.024	DNA-binding	Up
RNA-binding protein Raly	RALY	Q9UKM9	4.92	0.004	Ribonucleoprotein, RNA-binding	Up
Calponin-2	CNN2	Q99439	4.68	0.008	Actin-binding, Calmodulin-binding	Up
Aldo-keto reductase family 1 member B10	AKR1B10	O60218	4.29	0.017	Oxidoreductase	Up
Protein S100-A2	S100A2	P29034	4.13	0.024	Ligand	Up
Immunoglobulin lambda variable 6–57	IGLV6-57	P01721	3.69	0.012	Adaptive immunity	Up
Actin, alpha skeletal muscle	ACTA1	P68133	3.31	0.001	Hydrolase, Muscle protein	Up
Protein kinase C beta type	PRKCB	P05771	3.26	0.000	Kinase, Transferase	Up
Glucose-6-phosphate 1-dehydrogenase	G6PD	P11413	3.08	0.021	Oxidoreductase	Up
EH domain-binding protein 1-like protein 1	EHBP1L1	Q8N3D4	2.43	0.010	Unknown	Up
Testican-1	SPOCK1	Q08629	0.54	0.014	Unknown	Down
Bile salt-activated lipase	CEL	P19835	0.52	0.002	Hydrolase, Serine esterase	Down
GDP-mannose 4,6 dehydratase	GMDS	O60547	0.31	0.008	Lyase	Down
Uridine phosphorylase 1	UPP1	Q16831	0.23	0.004	Glycosyltransferase	Down

FC, Fold change

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ISSN: 1471-2369

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