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Table 3 Diagnostic performance for identifying aHUS at PLASMIC score cutoff ≤ 5 in the PINC AI™ database population

From: PLASMIC score to aid diagnosis of aHUS: an analysis of C5 inhibitor clinical trials and the PINC AI™ healthcare database

Diagnostic parameter

Primary Analysis

n = 110

Sensitivity Analysis #1

n = 157

Sensitivity Analysis #2

n = 81

Sensitivity, % (95% CI)

86.5 (79.4–93.6)

[77 / 89]

85.5 (78.9–92.0)

[94 / 110]

89.0 (81.9–96.2)

[65 /73]

Specificity, % (95% CI)

71.4 (52.1–90.8)

[15 / 21]

63.8 (50.1–77.6)

[30 / 47]

100

[8 / 8]

PPV, % (95% CI)

92.8 (87.2–98.3)

[77 / 83]

84.7 (78.0–91.4)

[94 / 111]

100

[65 / 65]

NPV, % (95% CI)

55.6 (36.8–74.3)

[15 / 27]

65.2 (54.5–79.0)

[30 / 46]

50.0 (25.5–74.5)

[8 / 16]

  1. Abbreviations: aHUS, atypical hemolytic uremic syndrome; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value
  2. Diagnostic performance for identifying aHUS at the PLASMIC Score cutoff of ≤ 5 in the primary analysis and sensitivity analyses patients from the PINC AI™ Database population
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BMC Nephrology

ISSN: 1471-2369

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