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Table 2 PLASMIC score and ADAMTS13 activity characteristics of patients in primary analysis from the PINC AI™ database (n = 110)

From: PLASMIC score to aid diagnosis of aHUS: an analysis of C5 inhibitor clinical trials and the PINC AI™ healthcare database

Characteristics

Overall

ADAMTS13 activity

PLASMIC Score

< 10%e

≥ 10%f

0 to 5

6 to 7

(n = 110)

(n = 21)

(n = 89)

(n = 83)

(n = 27)

PLASMIC Score components, n (%)

     

 Platelet count < 30 × 109 / La

41 (37.3)

18 (85.7)

23 (25.8)

18 (21.7)

23 (85.2)

  Hemolysisa, b

64 (58.2)

19 (90.5)

45 (50.6)

39 (47)

25 (92.6)

  No active cancer in the past year

68 (61.8)

11 (52.4)

57 (64.0)

45 (54.2)

23 (85.2)

  No history of solid organ or stem cell transplant

104 (94.5)

21 (100)

83 (93.3)

77 (92.8)

27 (100)

  Mean corpuscular volume < 9 × 10− 14 La, c

72 (65.5)

14 (66.7)

58 (65.2)

50 (60.2)

22 (81.5)

  International Normalization Ratio < 1.5a

94 (85.5)

20 (95.2)

74 (83.1)

68 (81.9)

26 (96.3)

  Creatinine < 2.0 mg / dLd

58 (52.7)

20 (95.2)

38 (42.7)

32 (38.6)

26 (96.3)

 ADAMTS13 activity level, %a

     

  Median (Q1, Q3)

57.5 (35, 83)

5 (5, 5)

67 (48, 85)

64 (46, 84)

5 (5, 55)

  1. Abbreviations: ADAMTS13, a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13; SD, standard deviation
  2. a Lowest measure available within the appropriate time frame
  3. b Hemolysis was defined as indirect bilirubin > 2 mg/dL (34.2 µmol/L) or reticulocyte count > 2.5% or undetectable haptoglobin
  4. c Equivalent to < 90 fL
  5. d Equivalent to 176.8 µmol/L
  6. e Consistent with a diagnosis of thrombotic thrombocytopenic purpura
  7. f Indicates a TMA other than thrombotic thrombocytopenia purpura