Skip to main content
Fig. 3 | BMC Nephrology

Fig. 3

From: Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway

Fig. 3

Celastrol decreased the TGase-2, HMGB1, TLR4 and MYD88 levels in the renal tissue of IgAN rats. (A) The protein levels of TGase-2, HMGB1, TLR4 and MYD8 in the renal tissue of IgAN rats were detected by western blots and quantization. (B) The mRNA levels of TGase-2, HMGB1, TLR4 and MYD8 in the renal tissue of IgAN rats were detected by RT-qPCR. C, control group; M, model group; CL-H, celastrol high dose group; CL-L, celastrol low dose group; MP, methylprednisolone group. Data are expressed as the means ± SD. *p < 0.05, **p < 0.01, ***p < 0.001 vs.the control group; ###p < 0.001, ##p < 0.01 vs. the model group

Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us