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Fig. 2 | BMC Nephrology

Fig. 2

From: Celastrol modulates damage of renal tissues in Immunoglobulin A nephropathy via targeting TGase-2/HMGB1 signaling pathway

Fig. 2

Renal tissue staining results of celastrol treated IgAN rats. (A) Immunofluorescence staining (×200) of IgA in renal tissues of rats in C group, M group, CL-H group, CL-L group and MP group. The mean fluorescence intensity of each group was analyzed. (B) Immunohistochemical detection (×400) of TGase-2 in renal tissues of rats in C group, M group, CL-H group, CL-L group and MP group. IOD value of each group was analyzed. (C) PAS staining (×400) of renal tissues of rats in C group, M group, CL-H group, CL-L group and MP group. Mesangial area ratio of each group (%). C, control group; M, model group; CL-H, celastrol high dose group; CL-L, celastrol low dose group; MP, methylprednisolone group. Data are expressed as the means ± SD. ***p < 0.001 vs.the control group; ###p < 0.001, ##p < 0.01, #p < 0.05 vs. the model group

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BMC Nephrology

ISSN: 1471-2369

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