Table 4 Key findings

• The SNV rs2808630 of CRP is not associated with CKD in the western Mexican population.

• The presence of this SNV does not appear to influence hs-CRP or IL-6 levels.

• hs-CRP levels in PLHIV remain similar between early and advanced CKD stages.

• Elevated IL-6 concentrations are associated with CKD, as determined by eGFR.

• IL-8 shows a stronger association with CKD in PLHIV.

• IL-18 is not linked to CKD progression in either group; however, follow-up studies may clarify whether IL-18 serves as a prognostic biomarker for cardiovascular protection.