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Table 5 Beta coefficients from multivariable linear regression analyses in all study subjects (CKD + controls)

From: Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate

 

log p-NfL (ng/L)

log p-p-Tau231 (ng/L)

log p-GFAP (ng/L)

Age, years

0.196***

−0.214***

0.494***

BMI, kg/m2

−0.119**

−0.005

−0.180**

mGFR, ml/min/1.73 m2

−0.658***

−0.357***

−0.446***

U-ACR, g/mol

0.112*

−0.005

−0.003

B-Hemoglobin, g/L

−0.034

−0.240***

−0.060

S-TnT, ng/L

0.172**

0.380***

0.043

Male gender

−0.014

0.044

−0.054

Smoking

−0.004

0.013

−0.053*

Diabetes

0.074*

0.041

0.021

  1. Dependent variables are log-transformed plasma concentrations of neurological biomarkers. Standardized beta coefficients are presented for continuous variables and unstandardized beta coefficients for categorical variables. BMI, body mass index; mGFR, measured glomerular filtration rate; eGFRcreatinine, estimated GFR based on plasma-creatinine; U-ACR, urine albumin-to-creatinine ratio; S-TnT, serum troponin T; NfL, neurofilament light chain; p-Tau231, phosphorylated Tau231; and GFAP, Glial fibrillary acidic protein. * denotes p < 0.05, ** denotes p < 0.01, *** denotes p < 0.001. N = 165
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BMC Nephrology

ISSN: 1471-2369

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