Skip to main content

Table 4 Spearman’s correlation coefficient between clinical variables and plasma concentrations of neurological biomarkers in all study subjects (CKD + controls)

From: Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate

 

P-NfL, ng/L

P-p-Tau231, ng/L

P-GFAP, ng/L

Age, years

0.180*

−0.132

0.433***

BMI, kg/m2

0.069

0.098

−0.102

B-Hemoglobin, g/L

−0.390***

−0.442***

−0.260**

mGFR, ml/min/1.73 m2

−0.846***

−0.735***

−0.449***

eGFRcreatinine, ml/min/1.73 m2

−0.822***

−0.730***

−0.402***

U-ACR, mg/mmol

0.588***

0.587***

0.186*

Carotid-femoral PWV, m/s

0.323***

0.147

0.376***

S-TnT, ng/L

0.640***

0.539***

0.378***

P-NfL, ng/L

–

0.714***

0.605***

P-p-Tau231, ng/L

0.714***

–

0.336***

  1. BMI, body mass index; mGFR, measured glomerular filtration rate; eGFRcreatinine, estimated GFR based on plasma-creatinine; U-ACR, urine albumin-to-creatinine ratio; PWV, pulse-wave velocity; S-TnT, serum troponin T; NfL, neurofilament light chain; p-Tau231, phosphorylated Tau231; and GFAP, Glial fibrillary acidic protein. * denotes p < 0.05, ** denotes p < 0.01, *** denotes p < 0.001. N = 165