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Table 1 General characteristics

From: Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate

 

CKD (n = 110)

Healthy controls (n = 55)

P-value

Age, years

61 ± 12

64 ± 11

0.038

Men (%)

75 (68)

31 (56)

n.s.

Body weight, kg

83 ± 16

75 ± 14

0.002

BMI, kg/m2

27.0 ± 3.8

25.1 ± 3.3

0.001

Current or former smoker (%)

55 (50)

14 [26]

0.003

Hypertension (%)

96 (87)

0

<0.001

Diabetes (%)

31 (28)

0

<0.001

Atherosclerotic CV disease (%)

16 (15)

0

0.001

Ambulatory SBP, mmHg

124 ± 15

120 ± 12

n.s.

Ambulatory DBP, mmHg

73 ± 10

72 ± 7

n.s.

Carotid-femoral PWV, m/s

9.6 ± 2.7

8.7 ± 2.0

n.s.

mGFR, ml/min/1.73 m2

36 ± 15

85 ± 13

<0.001

S-creatinine, µmol/L

184 ± 72

76 ± 12

<0.001

S-cystatin c, mg/L

2.00 ± 0.66

0.92 ± 0.14

<0.001

U-ACR, mg/mmol

15 (3–73)

0 (0.0–0.4)

<0.001

B-Hemoglobin, g/L

127 ± 14

136 ± 11

<0.001

S-hsCRP, mg/L

3.25 ± 4.04

1.44 ± 2.03

<0.001

P-ApoB/ApoA1

0.75 ± 0.28

0.66 ± 0.17

0.030

S-phosphate, mmol/L

1.11 ± 0.23

1.02 ± 0.15

n.s.

S-PTH, pmol/L

10.9 ± 8.1

5.4 ± 1.7

<0.001

S-FGF-23, ng/L

185 ± 165

69 ± 19

<0.001

S-TnT, ng/L

13.1 (8.0–19.0)

5.7 (0.0–9.4)

<0.001

S-NTpro-BNP, ng/L

151 (78–285)

55 (33–98)

<0.001

  1. Values are means ± SD or median (IQR). CKD, chronic kidney disease; BMI, body mass index; CV, cardiovascular; SBP, systolic blood pressure; DBP, diastolic blood pressure; mGFR, measured glomerular filtration rate, PWV, pulse-wave velocity; U-ACR, urine albumin-to-creatinine ratio; hsCRP, high-sensitivity c-reactive protein; PTH, parathyroid hormone; FGF-23, fibroblast growth-factor-23; S-TnT, serum troponin T; BNP, brain natriuretic peptide, and n.s., not significant. P-values are for the Mann-Whitney U test and for Chi-square with Fisher’s exact test