Inflammatory and nutritional indices for overall survival in Hemodialysis patients: a multicenter cohort study

Chen, Xinpan; Wang, Gang; Yin, Xiayan; Liu, Wenhu; Huang, Hongdong; Li, Dishan

doi:10.1186/s12882-025-04121-3

BMC Nephrology

Table 2 Relationships between different indicators and overall survival

From: Inflammatory and nutritional indices for overall survival in Hemodialysis patients: a multicenter cohort study

	Crude model		Model A		Model B
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
PNI
As continuous (per SD)	0.68 (0.66–0.71)	< 0.01	0.73 (0.70–0.76)	< 0.01	0.78 (0.75–0.82)	< 0.01
By PNI cut-off
Low (< 42.3)	Ref		Ref		Ref
High (≥ 42.3)	0.49 (0.45–0.53)	< 0.01	0.57 (0.52–0.62)	< 0.01	0.63 (0.58–0.69)	< 0.01
Interquartile
Q1 (< 39.9)	Ref		Ref		Ref
Q2 (39.9-43.95)	0.64 (0.57–0.71)	< 0.01	0.66 (0.59–0.73)	< 0.01	0.72 (0.64–0.80)	< 0.01
Q3 (43.95–47.95)	0.49 (0.44–0.55)	< 0.01	0.55 (0.49–0.61)	< 0.01	0.62 (0.55–0.69)	< 0.01
Q4 (≥ 47.95)	0.35 (0.31–0.40)	< 0.01	0.44 (0.39–0.50)	< 0.01	0.52 (0.46–0.59)	< 0.01
P for trend		< 0.01		< 0.01		< 0.01
LCR
As continuous (per SD)	0.76 (0.70–0.82)	< 0.01	0.76 (0.71–0.82)	< 0.01	0.75 (0.70–0.81)	< 0.01
By LCR cut-off
Low (< 1724.9)	Ref		Ref		Ref
High (≥ 1724.9)	0.54 (0.50–0.59)	< 0.01	0.58 (0.53–0.63)	< 0.01	0.65 (0.60–0.71)	< 0.01
Interquartile
Q1 (< 1059.7)	Ref		Ref		Ref
Q2 (1059.7-3363.6)	0.72 (0.65–0.80)	< 0.01	0.70 (0.63–0.78)	< 0.01	0.77 (0.70–0.86)	< 0.01
Q3 (3363.6-10356.2)	0.53 (0.47–0.59)	< 0.01	0.56 (0.50–0.63)	< 0.01	0.67 (0.60–0.75)	< 0.01
Q4 (≥ 10356.2)	0.42 (0.37–0.48)	< 0.01	0.46 (0.41–0.52)	< 0.01	0.53 (0.47–0.60)	< 0.01
P for trend		< 0.01		< 0.01		< 0.01
CAR
As continuous (per SD)	1.11 (1.09–1.13)	< 0.01	1.10 (1.08–1.12)	< 0.01	1.09 (1.07–1.12)	< 0.01
By CAR cut-off
Low (< 0.189)	Ref		Ref		Ref
High (≥ 0.189)	2.06 (1.90–2.24)	< 0.01	1.88 (1.73–2.04)	< 0.01	1.83 (1.68–1.99)	< 0.01
Interquartile
Q1 (< 0.027)	Ref		Ref		Ref
Q2 (0.027–0.083)	1.36 (1.18–1.56)	< 0.01	1.30 (1.13–1.49)	< 0.01	1.32 (1.15–1.52)	< 0.01
Q3 (0.083–0.274)	1.71 (1.50–1.96)	< 0.01	1.58 (1.38–1.81)	< 0.01	1.60 (1.40–1.84)	< 0.01
Q4 (≥ 0.274)	2.76 (2.43–3.14)	< 0.01	2.43 (2.14–2.76)	< 0.01	2.37 (2.08–2.71)	< 0.01
P for trend		< 0.01		< 0.01		< 0.01
SII
As continuous (per SD)	1.06 (1.02–1.10)	0.01	1.06 (1.02–1.10)	< 0.01	1.06 (1.02–1.10)	< 0.01
By SII cut-off
Low (< 1456.9)	Ref		Ref		Ref
High (≥ 1456.9)	1.25 (1.11–1.40)	< 0.01	1.27 (1.13–1.43)	< 0.01	1.17 (1.04–1.32)	< 0.01
Interquartile
Q1 (< 406.7)	Ref		Ref		Ref
Q2 (406.7-617.9)	0.96 (0.85–1.07)	0.45	1.01 (0.90–1.13)	0.88	0.95 (0.84–1.07)	0.38
Q3 (617.9-1028.2)	0.99 (0.88–1.11)	0.86	1.05 (0.94–1.18)	0.37	0.99 (0.88–1.11)	0.90
Q4 (≥ 1028.2)	1.12 (1.00-1.26)	0.05	1.22 (1.08–1.37)	< 0.01	1.08 (0.96–1.21)	0.23
P for trend		0.06		< 0.01		0.19
PLR
As continuous (per SD)	1.03 (0.99–1.06)	0.17	1.03 (0.99–1.06)	0.18	1.02 (0.98–1.05)	0.37
By PLR cut-off
Low (< 219.3)	Ref		Ref		Ref
High (≥ 219.3)	1.21 (1.10–1.34)	< 0.01	1.21 (1.10–1.34)	< 0.01	1.10 (1.00-1.22)	0.06
Interquartile
Q1 (< 107.3)	Ref		Ref		Ref
Q2 (107.3-147.8)	0.96 (0.86–1.08)	0.51	1.04 (0.93–1.17)	0.50	0.98 (0.87–1.10)	0.71
Q3 (147.8-209.5)	0.96 (0.85–1.07)	0.45	1.04 (0.93–1.17)	0.48	0.98 (0.87–1.10)	0.71
Q4 (≥ 209.5)	1.11 (0.99–1.25)	0.07	1.18 (1.06–1.33)	< 0.01	1.03 (0.92–1.16)	0.60
P for trend		0.11		< 0.01		0.64
NLR
As continuous (per SD)	1.06 (1.02–1.11)	< 0.01	1.06 (1.02–1.11)	< 0.01	1.07 (1.03–1.12)	< 0.01
By NLR cut-off
Low (< 4.89)	Ref		Ref		Ref
High (≥ 4.89)	1.23 (1.12–1.35)	< 0.01	1.24 (1.13–1.36)	< 0.01	1.19 (1.08–1.3)	< 0.01
Interquartile
Q1 (< 2.57)	Ref		Ref		Ref
Q2 (2.57–3.54)	1.02 (0.91–1.15)	0.71	1.09 (0.97–1.23)	0.13	1.03 (0.91–1.16)	0.64
Q3 (3.54–5.25)	1.07 (0.95–1.20)	0.28	1.14 (1.01–1.28)	0.03	1.08 (0.96–1.21)	0.20
Q4 (≥ 5.25)	1.22 (1.09–1.37)	< 0.01	1.30 (1.16–1.46)	< 0.01	1.20 (1.07–1.35)	< 0.01
P for trend		< 0.01		< 0.01		< 0.01

Crude model: unadjusted; Model A: adjusted for sex and age; Model B: adjusted for sex, age, diabetes, hypertension, hemoglobin level, lymphocyte count, platelet count, neutrophil count, albumin, creatinine, urea, calcium, phosphorus, parathormone, Fe, ferritin, TIBC and CRP, except for the indicator associated variable

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