Table 5 Incidence of adverse events in C3G+P cohort compared to healthy pregnancies and other glomerular diseases. Incidence rates of adverse events in C3G + P, compared to that of the healthy population and pregnancies of individuals with MPGN Type 1, IgA Nephropathy, and generalized glomerular disease (CureGN). CureGN cohort is pregnancies occurring after diagnosis of minimal change disease (MCD), membranous nephropathy, FSGS and IgA nephropathy or vasculitis. “Complicated pregnancies” included at least one of the following: worsening blood pressure, worsening kidney function, increased proteinuria, preeclampsia, eclampsia, or HELLP. P-values were calculated using two-proportion two-tailed z-test
From: Pregnancy outcomes in C3 glomerulopathy: a retrospective review
Outcomes | C3G + P Cohort Prevalence (95% CI) | Healthy Pregnancy | MPGN Type 1 [3] | IgA Nephropathy [18] | CureGN Cohort [10] | ||||
|---|---|---|---|---|---|---|---|---|---|
Prevalence | P value | Prevalence (95% CI) | P value | Prevalence (95% CI) | P value | Prevalence | P value | ||
Prematurity (< 37 weeks) | 44% (24–64%) | 11% (CDC 2021 [24]) | < 0.001 | 29% (18–41%) | 0.17 | 8% (6–13%) | < 0.001 | 25% | 0.09 |
Spontaneous Miscarriage | 14% (2–25%) | 10% (ACOG 2018 [25]) | 0.42 | 24% (13–35%) | 0.23 | 15% (11–20%) | 0.87 | 10% | 0.56 |
Preeclampsia | 59% (39–79%) | 4% (JAMA 2017 [26]) | < 0.001 | 31% “complicated by HTN” (19–43%) | 0.01 | 7% (5–11%) | < 0.001 | 48% “complicated pregnancies” | 0.36 |