Table 1 Study population definitions. Definitions of outcomes examined in this study. Genetic variants of unknown significance were reported in 10 of 32 mothers. For the purposes of our calculations, these variants were not considered driver of diseases and are included in Supplemental Table 2

Adverse Event of Pregnancy

All forms of pregnancy loss (besides elective abortion), the development of preeclampsia or eclampsia, premature delivery, or delivery of a low-birth-weight infant

Premature Birth

Delivery before 37 weeks’ gestation

Low Birth Weight

Infant weighing less than 5.5 lb. (or 2500 g - <10th percentile for gestational age) at time of delivery.

Positive Driver of Disease

Pathogenic genetic variant (as classified according to ACMG guidelines), C3/C4/C5 nephritic factors, Factor B/Factor H autoantibodies, or monoclonal proteins. [20].