Does combining urine sediment examination to renal cell arrest and damage biomarkers improve prediction of progression and mortality of sepsis associated acute kidney injury?

Table 5 Urine sediment scores, renal cell arrest and damage markers as a predictors for mortality

	AUC	p	95% C.I	Cut off	Sensitivity	Specificity	PPV	NPV
IGFBP-7 × TIMP-2	0.679	0.004^*	0.564–0.794	> 0.3	87.5	21.9	35.9	77.8
				> 2	31.3	85.9	52.6	71.4
KIM-1	0.626	0.045^*	0.509–0.742	> 1295	65.62	56.25	42.9	76.6
P1	0.599	0.116	0.472–0.725	≥ 1	75.0	29.7	34.8	70.4
				≥ 2	40.6	81.3	52.0	73.2
				≥ 3	6.3	98.4	66.7	67.7
P2	0.750	< 0.001^*	0.650–0.849	≥ 1	96.9	25.0	39.2	94.1
				≥ 2	87.5	54.7	49.1	89.7
				≥ 3	53.1	79.7	56.7	77.3
P3	0.762	0.001^*	0.631–0.894	≥ 1	85.7	32.7	35.3	84.2
				≥ 2	85.7	57.1	46.2	90.3
				≥ 3	71.4	79.6	60.0	86.7
C1	0.588	0.161	0.467–0.709	≥ 2	62.5	54.7	40.8	74.5
				≥ 3	3.1	98.4	50.0	67.0
C2	0.779	< 0.001^*	0.681–0.877	≥ 2	90.6	48.4	46.8	91.2
				≥ 3	62.5	82.8	64.5	81.5
C3	0.770	< 0.001^*	0.648–0.891	≥ 2	85.7	57.1	46.2	90.3
				≥ 3	66.7	79.6	58.3	84.8
Combinations
P2 + C2	0.793	< 0.001^*	0.699–0.886		62.5	82.8	64.5	81.5
P2 + C2 + IGFBP-7 × TIMP-2	0.807	< 0.001^*	0.712–0.903		65.6	81.3	63.6	82.5
P2 + C2 + KIM-1	0.796	< 0.001^*	0.699–0.893		62.5	82.8	64.5	81.5
IGFBP-7 × TIMP-2 + KIM-1	0.691	0.002^*	0.582–0.801		25.0	90.6	57.1	70.7
P2 + C2 + IGFBP-7 × TIMP-2 + KIM-1	0.803	< 0.001^*	0.705–0.900		62.5	81.3	62.5	81.3
P2 + C2 + UOP + PCT + Sofa + ACR + IGFBP-7 × TIMP-2 + KIM-1	0.848	< 0.001^*	0.772–0.924		65.6	81.3	63.6	82.5

AUC: Area Under a Curve p value: Probability value CI: Confidence Intervals
NPV: Negative predictive value PPV: Positive predictive value
*: Statistically significant at p ≤ 0.05
P1, P2 and P3: Perazella score at day 1, 3 and 7 respectively
C1, C2 and C3: Chawla score at day 1, 3 and 7 respectively
ACR: albumin to creatinine ratio, IGFBP-7: insulin-like growth factor binding protein 7, KIM-1: kidney injury molecule-1, PCT: procalcitonin, SOFA: Sequential Organ Failure Assessment, TIMP-2: tissue inhibitor of metalloproteinase 2, UOP: urine output

ISSN: 1471-2369