Does combining urine sediment examination to renal cell arrest and damage biomarkers improve prediction of progression and mortality of sepsis associated acute kidney injury?

Table 4 Urine sediment scores, renal cell arrest and damage markers as predictors for AKI progression

	AUC	p	95% C.I	Cut off	Sensitivity	Specificity	PPV	NPV
IGFBP-7 × TIMP-2	0.837	< 0.001^*	0.755–0.918	> 0.3	97.8	34.0	57.7	94.4
				> 2	39.1	98.0	94.7	63.6
KIM-1	0.657	0.008^*	0.549–0.766	> 1295	65.22	62.0	61.2	66.0
P1	0.605	0.077	0.491–0.719	≥ 1	76.1	32.0	50.7	59.3
				≥ 2	37.0	84.0	68.0	59.2
				≥ 3	4.3	98.0	66.7	52.7
P2	0.893	< 0.001^*	0.828–0.957	≥ 1	100.0	34.0	58.2	100.0
				≥ 2	93.5	72.0	75.4	92.3
				≥ 3	58.7	94.0	90.0	71.2
P3	0.934	< 0.001^*	0.872–0.996	≥ 1	97.1	51.4	66.7	94.7
				≥ 2	94.3	82.9	84.6	93.5
				≥ 3	68.6	97.1	96.0	75.6
C1	0.634	0.024^*	0.522–0.746	≥ 2	65.2	62.0	61.2	66.0
				≥ 3	2.2	98.0	50.0	52.1
C2	0.920	< 0.001^*	0.867–0.974	≥ 2	97.8	66.0	72.6	97.1
				≥ 3	65.2	98.0	96.8	75.4
C3	0.947	< 0.001^*	0.892–1.000	≥ 2	97.1	85.7	87.2	96.8
				≥ 3	65.7	97.1	95.8	73.9
Combinations
P2 + C2	0.944	< 0.001^*	0.905–0.984		91.3	78.0	79.2	90.7
P2 + C2 + IGFBP-7 × TIMP-2	0.977	< 0.001^*	0.951–1.000		91.3	94.0	93.3	92.2
P2 + C2 + KIM-1	0.951	< 0.001^*	0.914–0.988		87.0	88.0	87.0	88.0
IGFBP-7 × TIMP-2 + KIM-1	0.843	< 0.001^*	0.767–0.919		56.5	86.0	78.8	68.3
P2 + C2 + IGFBP-7 × TIMP-2 + KIM-1	0.979	< 0.001^*	0.954–1.000		93.5	96.0	95.6	94.1
P2 + C2 + UOP + PCT + Sofa + ACR + IGFBP-7 × TIMP-2 + KIM-1	0.985	< 0.001^*	0.967–1.000		93.5	100.0	100.0	94.3

AUC: Area Under a Curve p value: Probability value CI: Confidence Intervals
NPV: Negative predictive value PPV: Positive predictive value
*: Statistically significant at p ≤ 0.05
P1, P2 and P3: Perazella score at day 1, 3 and 7 respectively
C1, C2 and C3: Chawla score at day 1, 3 and 7 respectively
ACR: albumin to creatinine ratio, IGFBP-7: insulin-like growth factor binding protein 7, KIM-1: kidney injury molecule-1, PCT: procalcitonin, SOFA: Sequential Organ Failure Assessment, TIMP-2: tissue inhibitor of metalloproteinase 2, UOP: urine output

ISSN: 1471-2369