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Table 3 Renal cell arrest and damage markers and urine sediment scores in study patients

From: Does combining urine sediment examination to renal cell arrest and damage biomarkers improve prediction of progression and mortality of sepsis associated acute kidney injury?

 

Total

Progression

p

No

Yes

IGFBP-7 × TIMP-2 (ng/ml)2/1000)

0.48 (0.33–0.75)

0.34 (0.16–0.46)

0.66 (0.49–2.17)

< 0.001*

KIM-1 (pg/ml)

1310 (1070–1545)

1235 (875–1505)

1437.5 (1150–1690)

0.008*

P1

(n = 96)

(n = 50)

(n = 46)

 

 0

27 (28.1%)

16 (32.0%)

11 (23.9%)

0.125

 1

44 (45.8%)

26 (52.0%)

18 (39.1%)

 2

22 (22.9%)

7 (14.0%)

15 (32.6%)

 3 or more

3 (3.1%)

1 (2.0%)

2 (4.3%)

P2

(n = 96)

(n = 50)

(n = 46)

 

 0

17 (17.7%)

17 (34.0%)

0 (0.0%)

< 0.001*

 1

22 (22.9%)

19 (38.0%)

3 (6.5%)

 2

27 (28.1%)

11 (22.0%)

16 (34.8%)

 3 or more

30 (31.3%)

3 (6.0%)

27 (58.7%)

P3

(n = 70)

(n = 35)

(n = 35)

 

 0

19 (27.1%)

18 (51.4%)

1 (2.9%)

< 0.001*

 1

12 (17.1%)

11 (31.4%)

1 (2.9%)

 2

14 (20.0%)

5 (14.3%)

9 (25.7%)

 3 or more

25 (35.7%)

1 (2.9%)

24 (68.6%)

C1

(n = 96)

(n = 50)

(n = 46)

 

 1

47 (49.0%)

31 (62.0%)

16 (34.8%)

0.018*

 2

47 (49.0%)

18 (36.0%)

29 (63.0%)

 3 or more

2 (2.1%)

1 (2.0%)

1 (2.2%)

C2

(n = 96)

(n = 50)

(n = 46)

 

 1

34 (35.4%)

33 (66.0%)

1 (2.2%)

< 0.001*

 2

31 (32.3%)

16 (32.0%)

15 (32.6%)

 3 or more

31 (32.3%)

1 (2.0%)

30 (65.2%)

C3

(n = 70)

(n = 35)

(n = 35)

 

 1

31 (44.3%)

30 (85.7%)

1 (2.9%)

< 0.001*

 2

15 (21.4%)

4 (11.4%)

11 (31.4%)

 3 or more

24 (34.3%)

1 (2.9%)

23 (65.7%)

  1. Qualitative data were described using number and percent and not normally distributed data was expressed in Median (IQR)
  2. p: p value for comparing between the two studied groups
  3. *: Statistically significant at p ≤ 0.05
  4. P1, P2 and P3: Perazella score at day 1, 3 and 7 respectively
  5. C1, C2 and C3: Chawla score at day 1, 3 and 7 respectively
  6. IGFBP-7: insulin-like growth factor binding protein 7, KIM-1: kidney injury molecule-1, TIMP-2: tissue inhibitor of metalloproteinase 2