Table 1 Description of the experimental groups
Group | Anesthesia Method | Surgical Procedure | Treatment | Ischemic Procedure | Reperfusion Time |
|---|---|---|---|---|---|
Control Group (N = 7) | 50 mg/kg ketamine + 10 mg/kg xylazine (i.p.) | Laparotomy, bilayer abdominal incision model | Sterile saline (5% body weight) 30 min before the surgical procedures | - | 24 h reperfusion |
IR Group (N = 7) | 50 mg/kg ketamine + 10 mg/kg xylazine (i.p.) | Laparotomy, suprarenal aorta clamping, bilayer abdominal incision model | Sterile saline (5% body weight) 30 min before the surgical procedures | 60 min of ischemia | 24 h reperfusion |
Treatment Group 1 (TR1) (N = 7) | 50 mg/kg ketamine + 10 mg/kg xylazine (i.p.) | Laparotomy, suprarenal aorta clamping, bilayer abdominal incision model | 0.5 mg/kg Adropin (i.p.) application 30 min before the surgical procedures | 60 min of ischemia | 24 h reperfusion |
Treatment Group 2 (TR2) (N = 7) | 50 mg/kg ketamine + 10 mg/kg xylazine (i.p.) | Laparotomy, suprarenal aorta clamping, bilayer abdominal incision model | 1 mg/kg Adropin (i.p.) 30 min before the surgical procedures | 60 min of ischemia | 24 h reperfusion |
Treatment Group 3 (TR3) (N = 7) | 50 mg/kg ketamine + 10 mg/kg xylazine (i.p.) | Laparotomy, suprarenal aorta clamping, bilayer abdominal incision model | 1.5 mg/kg Adropin (i.p.) 30 min before the surgical procedures | 60 min of ischemia | 24 h reperfusion |