Urinary biomarkers in prediction of subclinical acute kidney injury in pediatric oncology patients treated with nephrotoxic agents

Table 3 Diagnostic potency of urinary biomarkers’ for AKI status by using ROC curve analysis

Parameter	AUC (95th CI)	SE	Cut-off Value	Sensitivity	Sp	P
uNGAL/uCr baseline (ng/mg)	0.542 (0.276–0.807)	0.135	355.99	0.5	0.3	0.758
uNGAL/uCr at 2 h post-CT (ng/mg)	0.641 (0.367–0.914)	0.140	1373.50	0.5	0.2	0.313
uNGAL/uCr at 6 h post-CT (ng/mg)	0.677 (0.405–0.949)	0.139	4840.50	0.5	0.1	0.202
uNGAL/uCr at 24 h post-CT (ng/mg)	0.719 (0.513–0.925)	0.105	434.53	0.8	0.6	0.037
uKIM-1/uCr baseline (ng/mg)	0.628 (0.376–0.879)	0.128	4.62	0.7	0.6	0.320
uKIM-1/uCr at 2 h post-CT (ng/mg)	0.635 (0.432–0.838)	0.104	34.40	0.8	0.5	0.191
uKIM-1/uCr at 6 h post-CT (ng/mg)	0.750 (0.541–0.959)	0.107	9.17	0.7	0.8	0.019
uKIM-1/uCr at 24 h post-CT (ng/mg)	0.708 (0.521–0.896)	0.096	21.59	1.0	0.5	0.029
uL-FABP/uCr baseline (ng/mg)	0.510 (0.230–0.791)	0.143	34.27	0.3	0.8	0.942
uL-FABP/uCr at 2 h post-CT (ng/mg)	0.583 (0.328–0.838)	0.130	66.12	0.7	0.6	0.522
uL-FABP/uCr at 6 h post-CT (ng/mg)	0.672 (0.468–0.876)	0.104	75.84	0.8	0.6	0.099
uL-FABP /uCr at 24 h post-CT (ng/mg)	0.813 (0.665–0.960)	0.075	31.78	1.0	0.6	< 0.001
uVNN-1/uCr baseline (ng/mg)	0.630 (0.391–0.870)	0.122	6.48	0.8	0.4	0.287
uVNN-1/uCr at 2 h post-CT (ng/mg)	0.464 (0.231–0.696)	0.119	74.31	0.7	0.5	0.758
uVNN-1/uCr at 6 h post-CT (ng/mg)	0.464 (0.213–0.714)	0.128	42.67	0.5	0.6	0.775
uVNN-1/uCr at 24 h post-CT (ng/mg)	0.521 (0.258–0.783)	0.134	39.72	0.7	0.6	0.876

AKI – acute kidney injury, AUC – area under the curve, CI – confidence interval, SE – standard error; Sn - sensitivity; Sp - specificity; uNGAL – urinary neutrophil gelatinase-associated lipocalin; uCr – urine creatinine; CT – chemotherapy; uKIM-1 – urinary kidney injury molecule-1; uL-FABP – urinary liver fatty acid binding protein; uVNN-1 – urinary Vanin-1

ISSN: 1471-2369