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Fig. 10 | BMC Nephrology

Fig. 10

From: Novel insights into the molecular mechanisms of sepsis-associated acute kidney injury: an integrative study of GBP2, PSMB8, PSMB9 genes and immune microenvironment characteristics

Fig. 10

Validation of the expression of three core genes in animal experiments. (A-B) Measurement of serum biochemical indicators in mice, including serum creatinine and blood urea nitrogen (n = 6). (C-D) HE staining to observe morphological changes in the kidneys and to score tubular injury (n = 6) (original magnification × 400). Scale bar = 50 micrometers. (E-G) Detection of mRNA levels of GBP2, PSMB8, and PSMB9 in mice using qPCR. (H-I) Representative Western blot images and quantification of GBP2, PSMB8, and PSMB9 expression in mouse kidney tissues. (J) Immunohistochemical staining of GBP2, PSMB8, and PSMB9 in mouse kidneys. Magnification: × 400, scale bar = 50 μm (* p < 0.05, ** p < 0.01)

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BMC Nephrology

ISSN: 1471-2369

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