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Table 4 Comparison of two-year outcomes by days to surgery to close PDA

From: Association of patent ductus arteriosus treatment in extremely low gestational age neonates with two year kidney outcomes: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT)

 

0–14 days (n = 11)

15–29 days (n = 36)

≥ 30 days (n = 21)

p-value*

eGFR < 90 (n = 38)

0/8 (0.0)

2/22 (9.1)

4/11 (36.4)

0.08

ACR > 30 (n = 50)

3/8 (37.5)

10/28 (35.7)

3/14 (21.4)

0.70

Hypertension (n = 51)

    

 Systolic pressure-based

    

<90th  percentile

6/7 (85.7)

20/26 (76.9)

14/18 (77.8)

0.31

  90-94th  percentile

1/7 (14.3)

0/26 (0.0)

1/18 (5.6)

 

  ≥95th  percentile

0/7 (0.0)

6/26 (23.1)

3/18 (16.7)

 

 Diastolic pressure-based

    

  <90th  percentile

4/7 (57.1)

13/26 (50.0)

9/18 (50.0)

0.93

  90-94th  percentile

0/7 (0.0)

4/26 (15.4)

3/18 (16.7)

 

  ≥95th  percentile

3/7 (42.9)

9/26 (34.6)

6/18 (33.3)

 
  1. *Estimated from a Fisher’s exact test
  2. ACR: albumin/creatinine ratio