Table 3 Comparison of two-year outcomes by exposure to non-steroidal anti-inflammatory drugs and acetaminophen within days of life 4 to 28
Indomethacin day 4–28 (n = 129) | Ibuprofen day 4–28 (n = 40) | Acetaminophen day 4–28 (n = 3) | Combination (n = 15) | p-value* | |
|---|---|---|---|---|---|
eGFR < 90 (n = 115) | 14/74 (18.9) | 2/28 (7.1) | 0/2 (0.0) | 5/11 (45.5) | 0.05 |
ACR > 30 (n = 123) | 27/76 (35.5) | 9/33 (27.3) | 2/3 (66.7) | 5/11 (45.5) | 0.40 |
Hypertension (n = 148) | |||||
Systolic pressure-based | |||||
<90th percentile | 73/105 (69.5) | 23/30 (76.7) | 1/1 (100.0) | 8/12 (66.7) | 0.92 |
90-94th percentile | 7/105 (6.7) | 2/30 (6.7) | 0/1 (0.0) | 1/12 (8.3) | |
≥95th percentile | 25/105 (23.8) | 5/30 (16.7) | 0/1 (0.0) | 3/12 (25.0) | |
Diastolic pressure-based | |||||
<90th percentile | 49/105 (46.7) | 17/30 (56.7) | 1/1 (100.0) | 7/12 (58.3) | 0.74 |
90-94th percentile | 13/105 (12.4) | 2/30 (6.7) | 0/1 (0.0) | 2/12 (16.7) | |
≥95th percentile | 43/105 (40.9) | 11/30 (36.7) | 0/1 (0.0) | 3/12 (25.0) |