Measuring bone metabolic activity in dialysis patients with renal osteodystrophy using [18F]-Sodium Fluoride positron emission tomography- comparison between static and dynamic measurements

Table 3 Blood clearance to bone and standardized bone uptake values according to turnover in dialysis patients

	Low turnover n = 6	Normal turnover n = 9	High turnover n = 11	p - value
K_i (mL/min/mL)
L1	0.034 (0.026–0.038)	0.049 (0.036–0.045)	0.056 (0.053–0.065)	0.001
L2	0.032 (0.027–0.037)	0.037 (0.035–0.048)	0.057 (0.053–0.063)	0.003
L3	0.030 (0.023–0.030)	0.038 (0.036–0.046)	0.058 (0.051–0.078)	< 0.001
L4	0.032 (0.026–0.037)	0.041 (0.036–0.046)	0.057 (0.048–0.075)	0.005
SUV (g/ml)
L1	5.4 (4.9–7.7)	6.4 (5.0–7.6)	7.8 (6.6–8.7)	0.3
L2	5.0 (4.4–7.8)	5.7 (5.1–7.5)	7.4 (6.1–8.2)	0.2
L3	4.8 (4.1–7.6)	5.9 (4.9–7.2)	7.1 (5.5–8.1)	0.2
L4	5.1 (4.6–7.6)	6.2 (5.0–7.1)	7.7 (5.2–8.1)	0.2
SUVR
L1 - L4	3.0 (2.3–3.8)	4.2 (2.8–4,4)	5.0 (3.9–6.1)	0.02
FUR_mean(mL/min/mL)
Hip	0.033 (0.029–0.038)	0.041 (0.035–0.048)	0.060 (0.050–0.071)	0.002
SUV_mean (g/ml)
Hip	5.9 (4.6–7.4)	5.9 (5.5–7.0)	7.7 (6.8–9.8)	0.04*

Variables are reported as median and interquartile range. Reported p values are based on comparison between high and low turnover/normal turnover. * The p value of SUV_mean hip is significant, but when doing pairwise comparison using Tukey´s method, there was no significant difference between the groups. SUVR reflects mean bone uptake in the lumbar spine corrected by mean blood uptake of fluoride 48–60 min fron initiation of the dynamic PET scan. Reported p values are based on comparisons between high and low bone turnover

ISSN: 1471-2369