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Table 3 Identification of potential risk factors of MN complicated with malignant tumors by univariate and multivariate regression analysis

From: Construction and validation of a predictive model for malignant tumors in patients with membranous nephropathy

Ā 

Univariable

Multivariable

Ā 

OR

95%CI

P value

OR

95%CI

P value

Male (%)

1.232

0.933–1.820

0.296

Ā Ā Ā 

Age (years)

1.041

1.026–1.057

< 0.001

1.026

0.987–1.066

0.201

PLA2R Ab (RU/mL)

0.999

0.999-1.000

0.300

Ā Ā Ā 

PLA2R Ab (+)

0.555

0.361–0.853

0.007

0.612

0.200-1.874

0.390

THSD7A Ab (ng/mL)

1.003

0.999–1.006

0.174

Ā Ā Ā 

Hb (g/L)

0.977

0.966–0.987

< 0.001

0.974

0.946–1.003

0.077

GLU (mmol/L)

1.367

1.090–1.715

0.007

1.268

0.812–1.979

0.296

ALB (g/L)

1.020

0.991–1.051

0.183

Ā Ā Ā 

ESR (mm/h)

1.018

1.0111.024

< 0.001

1.009

0.990–1.028

0.360

CRP (mg/L)

1.030

1.011–1.050

0.002

1.016

0.982–1.051

0.371

sCr (umol/L)

1.019

1.009–1.028

< 0.001

1.003

0.990–1.016

0.675

UA (umol/L)

1.001

0.998–1.003

0.530

Ā Ā Ā 

24hUTP (g)

1.059

1.004–1.117

0.034

1.032

0.883–1.206

0.692

Pathological stage

1.763

1.247–2.493

0.001

1.555

0.683–3.539

0.293

Tubular atrophy

1.194

1.009–1.414

0.040

0.798

0.510–1.248

0.323

Interstitial fibrosis

1.107

0.888–1.380

0.365

Ā Ā Ā 

Renal arteriole injury

2.592

1.978–3.398

< 0.001

1.560

0.797–3.052

0.194

IgG

2.551

1.791–3.632

< 0.001

2.147

0.957–4.815

0.064

IgM

2.941

2.240–3.863

< 0.001

1.053

0.524–2.118

0.884

IgA

7.148

3.923–13.023

< 0.001

2.980

1.071–8.291

0.036

C3

1.756

1.385–2.227

< 0.001

0.819

0.422–1.590

0.556

C4

2.872

2.031–4.062

< 0.001

0.737

0.289–1.878

0.523

C1q

7.018

3.877–12.706

< 0.001

1.162

0.205–6.567

0.865

IgG1

1.935

1.511–2.480

< 0.001

2.535

1.367–4.703

0.003

IgG2

8.476

4.929–14.574

< 0.001

5.185

1.689–15.917

0.004

IgG3

2.353

1.694–3.270

< 0.001

3.558

1.417–8.934

0.007

IgG4

0.506

0.379–0.674

< 0.001

0.435

0.194–0.974

0.043

PLA2R

2.217

1.670–2.944

< 0.001

3.167

1.559–6.431

0.001