Table 3 Summary of the agreement between the albumin to creatinine ratio (ACR) and protein to creatinine ratio (PCR) determined by test strip analysis as compared to the quantitative lab test in the validation cohort
QUANTITATIVE ACR | QUANTITATIVE ACR | QUANTITATIVE ACR | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SEMI-QUANTITATIVE ACR | Categories (mg albumin/g creatinine) | SEMI-QUANTITATIVE PCR | Categories (mg albumin/g creatinine) | Qualitative Protein Concentration | Categories (mg albumin/g creatinine) | ||||||||
Categories (mg albumin/g creatinine) | < 30 | ≥ 30 | Total | Categories (mg protein/g creatinine) | < 30 | ≥ 30 | Total | Categories (mg protein/g creatinine) | < 30 | ≥ 30 | Total | ||
< 30 | 696 | 17 | 713 | < 150 | 709 | 51 | 760 | Negative | 576 | 36 | 612 | ||
≥ 30 | 60 | 152 | 212 | ≥ 150 | 47 | 118 | 165 | Positive | 181 | 132 | 313 | ||
Total | 756 | 169 | 925 | Total | 756 | 169 | 925 | Total | 756 | 169 | 925 | ||
Agreement | 91.7% | Agreement | 89.4% | Agreement | 76.5% | ||||||||
Cohen’s kappa (Weighted) | 0.746 | Cohen’s kappa (Weighted) | 0.642 | Cohen’s kappa (Weighted) | 0.409 | ||||||||
Sensitivity | 89.9% (95%CI: 84.4–94.0%) | Sensitivity | 69.8% (95%CI: 62.3–76.6%) | Sensitivity | 78.6% (95%CI: 71.6 − 84.5% | ||||||||
Specificity | 92.1% (95%CI: 89.9–93.9%) | Specificity | 93.8% (95%CI: 91.8–95.4%) | Specificity | 76.1% (95%CI: 72.9 − 79.1%) | ||||||||
PPV | 71.7% (95%CI: 66.4–76.5%) | PPV | 71.5% (95%CI: 65.2–77.1%) | PPV | 42.2% (95%CI: 36.6 − 47.9%) | ||||||||
NPV | 97.6% (95%CI: 96.3–98.5) | NPV | 93.3% (95%CI: 91.7–94.6%) | NPV | 94.1% (9%CI: 92.0 − 95.9%) | ||||||||
LR+ | 11.3 (95%CI: 8.8–14.5) | LR+ | 11.2 (95%CI: 8.4–15.1) | LR+ | 3.3 (95%CI: 2.8–3.8) | ||||||||
LR- | 0.11 (95%CI: 0.07–0.17) | LR- | 0.32 (95%CI: 0.26–0.41) | LR- | 0.28 (95%CI: 0.21–0.38) | ||||||||
Predictive probability | 0.933 (95% CI: 0.905–0.960) | Predictive probability | 0.830 (95%CI: 0.787–0.873) | Predictive probability | 0.774 (95%CI: 0.735–0.814) | ||||||||