Fig.2
The common factors in MSCs secretome. MSCs secretome consists of soluble components (growth factors, cytokines, chemokines, and hormones) and non-soluble components in extracellular vesicles (EVs). The effects mediated by EVs depend on "cargo", including proteins, functional mRNAs, miRNAs, and lipids. CAT: catalase, CCL: chemokine (C–C motif) ligand, CXCL: chemokine (C-X-C motif) ligand, FGF: fibroblast growth factor, GPx: glutathione peroxidase, GSH: glutathione, GSTs: glutathione S‐transferases, HGF: hepatocyte growth factor, HIF: hypoxia-inducible factor, HO‐1: heme oxygenase‐1, IDO: indoleamine 2,3 dioxygenase, IGF-1: Insulin-like growth factor 1, INF-γ: interferon γ, IL: interleukin, MCP-1: monocyte chemoattractant protein-1, M-CSF: macrophagecolony stimulating factor, miR: microRNA, NO: nitric oxide, Nrf2: nuclear factor erythroid 2‐related factor 2, PDGF: platelet-derived growth factor, PGE2: prostaglandin E2, SDF-1: stromal cell-derived factor-1, SOD: superoxide dismutase, TGF-β: transforming growth factor-β, TNF-α: Tumor Necrosis Factor-α, VEGF: vascular endothelial growth factor