Table 1 Clinical baseline characteristics of PMN patients with different levels of proteinuria and renal function
Variables | Overall (n = 536) | Severe proteinuria (n = 355) | Non-severe proteinuria (n = 181) | P-value | eGFR < 90 mL/min/1.73 m2 (n = 149) | eGFR ≥ 90 mL/min/1.73 m2 (n = 387) | P-value |
|---|---|---|---|---|---|---|---|
Age (years) | 51 ± 14 | 51 ± 14 | 50 ± 15 | 0.176 | 59 ± 11 | 47 ± 13 | < 0.001 |
Male (n,%) | 331 (61.75%) | 240 (67.61%) | 91 (50.28%) | < 0.001 | 104 (69.8%) | 227 (58.66%) | 0.023 |
MN duration (months) | 4 (1, 12) | 4 (1, 12) | 4 (2, 12) | 0.442 | 6 (2, 18) | 4 (1, 11) | < 0.001 |
BMI (kg/m2) | 25.87 ± 3.91 | 26.37 ± 3.80 | 24.88 ± 3.96 | < 0.001 | 26.17 ± 3.61 | 25.75 ± 4.02 | 0.238 |
SBP (mmHg) | 136 ± 19 | 139 ± 19 | 131 ± 17 | < 0.001 | 141 ± 20 | 134 ± 18 | < 0.001 |
DBP (mmHg) | 84 ± 12 | 86 ± 11 | 80 ± 11 | < 0.001 | 86 ± 12 | 84 ± 11 | 0.110 |
Smoking (n, %) | 180 (33.58%) | 139 (39.15%) | 41 (22.65%) | < 0.001 | 64 (42.95%) | 116 (29.97%) | 0.006 |
Drinking (n, %) | 136 (25.37%) | 103 (29.01%) | 33 (18.23%) | 0.009 | 36 (24.16%) | 100 (25.84%) | 0.772 |
Hypertension | 304 (56.72%) | 207 (58.31%) | 97 (53.59%) | 0.342 | 105 (70.47%) | 199 (51.42%) | < 0.001 |
DM | 87 (16.23%) | 64 (18.03%) | 23 (12.71%) | 0.145 | 39 (26.17%) | 48 (12.40%) | < 0.001 |
CHD | 16 (2.99%) | 13 (3.66%) | 3 (1.66%) | 0.307 | 12 (8.05%) | 4 (1.03%) | < 0.001 |
Stroke | 32 (5.97%) | 20 (5.63%) | 12 (6.63%) | 0.789 | 21 (14.09%) | 11 (2.84%) | < 0.001 |
Hyperlipidemia | 430 (80.22%) | 298 (83.94%) | 132 (72.93%) | 0.004 | 125 (83.89%) | 305 (78.81%) | 0.229 |
Serum PLA2R-Ab (RU/mL) | 34.66 (4.01, 127.14) | 65.12 (11.19, 179.31) | 7.39 (1.33, 44.94) | < 0.001 | 27.50 (2.42, 115.14) | 35.29 (4.66, 134.88) | 0.273 |
HDL-C (mmol/L) | 1.28 ± 0.37 | 1.25 ± 0.36 | 1.33 ± 0.39 | 0.012 | 1.19 ± 0.33 | 1.31 ± 0.39 | < 0.001 |
LDL-C (mmol/L) | 4.04 (3.00, 5.50) | 4.42 (3.29, 5.94) | 3.65 (2.74, 4.46) | < 0.001 | 4.01 (2.99, 5.14) | 4.05 (3.00, 5.69) | 0.355 |
TC (mmol/L) | 7.19 ± 2.41 | 7.69 ± 2.52 | 6.20 ± 1.83 | < 0.001 | 6.99 ± 2.40 | 7.27 ± 2.42 | 0.225 |
TG (mmol/L) | 2.09 (1.43, 3.05) | 2.22 (1.52, 3.34) | 1.76 (1.35, 2.63) | < 0.001 | 2.26 (1.62, 3.33) | 2.01 (1.37, 2.90) | 0.024 |
FBG (mmol/L) | 5.10 ± 1.17 | 5.17 ± 1.27 | 4.98 ± 0.94 | 0.056 | 5.40 ± 1.27 | 4.99 ± 1.11 | 0.001 |
TyG index | 9.06 ± 0.66 | 9.15 ± 0.68 | 8.88 ± 0.58 | < 0.001 | 9.18 ± 0.63 | 9.01 ± 0.67 | 0.006 |
HbA1c (%) | 5.75 ± 0.75 | 5.79 ± 0.81 | 5.67 ± 0.61 | 0.055 | 6.00 ± 0.81 | 5.66 ± 0.70 | < 0.001 |
24 h urine protein (g/d) | 4.92 (2.84, 8.16) | 6.88 (4.95, 9.93) | 2.12 (1.48, 2.89) | < 0.001 | 5.59 (3.14, 9.71) | 4.69 (2.75, 7.65) | 0.004 |
Serum ALB (g/L) | 29.48 ± 6.37 | 27.35 ± 5.48 | 33.67 ± 5.90 | < 0.001 | 29.63 ± 6.76 | 29.43 ± 6.22 | 0.749 |
SUA (µmo/L) | 377.16 ± 91.12 | 379.21 ± 92.56 | 373.13 ± 88.34 | 0.459 | 397.36 ± 94.47 | 369.38 ± 88.7 | 0.002 |
BUN (mmol/L) | 4.9 (3.9, 6.2) | 5.0 (4.0, 6.4) | 4.7 (3.0. 7,6) | 0.032 | 6.3 (5.3, 8.5) | 4.5 (3.7, 5.5) | < 0.001 |
Scr (µmo/L) | 68 (58, 83) | 71 (60, 86) | 64 (55, 78) | 0.001 | 92 (83, 105) | 63 (54, 72) | < 0.001 |
eGFR (mL/min/1.73 m2) | 100.66 ± 26.44 | 99.19 ± 28.67 | 103.55 ± 21.16 | 0.047 | 69.16 ± 18.54 | 112.79 ± 17.5 | < 0.001 |
ESR (mm/h) | 29 (16, 51) | 34 (19, 56) | 23 (10, 36) | < 0.001 | 36 (23, 65) | 27 (14, 45) | < 0.001 |
CRP (mg/dL) | 0.20 (0.15, 0.32) | 0.20 (0.15, 0.32) | 0.18 (0.14, 0.31) | 0.030 | 0.24 (0.19, 0.47) | 0.18 (0.14, 0.27) | < 0.001 |
WBC (×109/L) | 6.82 ± 2.12 | 6.96 ± 2.24 | 6.55 ± 1.83 | 0.022 | 7.16 ± 2.14 | 6.69 ± 2.10 | 0.022 |
HGB (g/L) | 137 ± 20 | 137.92 ± 20.64 | 136.1 ± 18.16 | 0.295 | 132 ± 21 | 139 ± 19 | < 0.001 |