Table 1 Autopsy and Renal Biopsy Findings in Kidney-Involvement MF Patients

A. Autopsy Findings of Renal Involvement in MF Patients

 Swaminathan 2002 [8]

Case 1 (3y): proteinuria, erythrocyturia, AKI; Case 2 (7y): proteinuria, erythrocyturia, leukocyturia, granular cylinders, AKI

Case 1: thrombocytopenia, hyperbilirubinemia, progressive azotemia; Case 2: creatininemia

Case 1: scant interstitial lymphocytic infiltrate with preserved renal architecture; Case 2: complete replacement of renal parenchyma by atypical lymphocytes of variable size

Lethal

 Long 1974 [7]

Not reported

Eosinophilia, lymphocytosis or monocytosis

2/15 (13), not reported

Lethal

 Rappaport 1974 [10]

Not reported

Not reported

14/45 (31); tumour nodules, an interstitial infiltration with preservation of architecture, tumour cells in tubular epithelium et Bowman’s capsule

Lethal

 Epstein 1972 [21]

Not reported

Not reported

23/96 (24), not reported

Lethal

Cyr 1966 [22]

Not reported

Not reported

5/23 (22), not reported

Lethal

 Block 1963 [9]

Not reported

Uremia, elevated BUN

4/17 (23), nodular lymphomatous infiltrates

Lethal

B. Renal Biopsy findings Kidney-involvement of MF

 Kairouani 2012 [3]

At the time of diagnosis; nephrotic syndrome

hypoalbuminemia, thrombocytopenia,creatininemia et uraemia

Not reported

Unrelated comorbidities

 Cather 1998 [15]

Case 1 (15 mths): hematuria, proteinuria. Case 2 (12 mths): proteinuria

Case 1: decreased hgb, thrombocytopenia, creatininemia; Case 2: creatininemia

Case 1:focal segmental and to a lesser extent global glomerular sclerosis, tubule atrophy, diffuse lymphocytic inflammatory infiltrates; Case 2: segmental and global glomerular sclerosis, proliferation of mesangial matrix, tubule atrophy, focal interstitial monocytic infiltrates and arteriosclerosis

Stabile

 Torrelo 1990 [12]

5 y, nephrotic grade proteinuria, erythrocyturia, hyaline, granular and fatty cylinders

creatininemia,

uraemia, hypoproteinemia

Uneven mesangial matrix proliferation with mesangial space deposits

Stable

 Allon 1988 [11]

3 mths, nephrotic proteinuria,

leukocyturia,

erythrocyturia,

granular hyaline urine cylinders

Trace SC, creatininemia, hypoalbuminemia,

thrombocytopenia

Mesangial hypercellularity, interstitial infiltration of atypical lymphocytes

Not reported

 Averbuch 1984 [13]

3 w,proteinuria,

leukocyturia,

erythrocyturia,

granular cylinders,

increased hematocrit;

creatininemia, BUN

hypoalbuminemia

No glomerular changes, extensive interstitial edema with mixed lymphocytic infiltrate including eosinophils and plasma cells, tubular dilatation, focal degeneration, and necrosis of proximal tubule cells

Stabile

 Ramirez 1981 [14]

Case 1: at diagnosis; hematuria, leukocyturia. Case 2: 3 y; proteinuria, erythrocyturia, leukocyturia

Case 1: creatininemia and BUN; Case 2: leukocytosis, creatininemia and BUN

Mesangial proliferation

Not reported