Table 1 Cases of non-obstetric bilateral renal cortical necrosis related to tranexamic acid administration reported in the literature
Koo, et al. (14) | Levin, et al. (15) | Odabas, et al. (16) | Park, et al. (17) | Ko, et al. (13) | ||
|---|---|---|---|---|---|---|
Age (yr) / Sex | 37 / M | 24 / F | 21 / M | 49 / M | 82 / F | |
Indication of TXA | Hemoptysis complicating post-tuberculosis bronchiectasis | Hemorrhagic diathesis complicating acute promyelocytic leukemia | Epistaxis complicating hemophilia A | Traumatic hemothorax | Hematemesis following endoscopic papillectomy | |
Hemodynamic instability | No | NR | No | No | No | |
Cumulative dose of TXA (g) | 15 | NR | 12 | NR | 12 | |
Duration until AKI onset (d) | 6 | 2 | 3 | 1 | 4 | |
Anuria | Yes | Yes | Yes | Yes | Yes | |
Requirement of RRT | Yes | Yes | Yes | Yes | Yes | |
Duration until onset of RRT (d) | NR | 5 | 9 | NR | 4 | |
Recovery of renal function | Yes | No | NR | Yes | No | |
Time to renal recovery (wk) | 3 | NR | 32 | |||
Death | No | No | No | No | No | |