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Table 4 Association of eGFR level and risk of in-hospital in high-risk groups

From: Impact of estimated glomerular filtration rate (eGFR) on in-hospital mortality: an age- and HIV status-specific retrospective cohort study in Uganda

High-risk

Subgroup

Number of participants

Number of events

HR(95%CI)

β coefficient

P value

P for interaction

Gender

0.055

 Male

103

24

0.99(0.97–1.00)

−0.01

0.070

 

 Female

114

21

0.97(0.943–0.988)

−0.04

0.003

 

Age, yrs

0.046

 < 40

99

15

0.93(0.89–0.97)

−0.07

< 0.001

 

 40–60

70

17

0.98(0.966–0.999)

−0.02

0.039

 

 ≥ 60

46

13

0.98(0.950–1.006)

−0.03

0.113

 

Alcohol drinkers

0.203

 Never

127

23

0.97(0.954–0.991)

−0.03

0.004

 

 Current or ever

98

22

0.99(0.965–9.992)

−0.02

0.041

 

Cigarette smokers

0.251

 Never

194

36

0.98(0.968–0.991)

−0.02

 < 0.001

 

 Current or ever

31

9

0.99(0.994–1.015)

−0.01

0.595

 

Alcohol use disorders

0.315

 Yes

21

8

0.92(0.758–1.126)

−0.08

0.434

 

 No

204

37

0.99(0.974–0.995)

−0.02

0.006

 

Hypertension

0.882

 Yes

67

14

1.04(0.999–1.092)

 + 0.04

0.057

 

 No

158

31

0.97(0.955–0.982)

−0.03

< 0.001

 

Diabetes mellitus

0.921

 Yes

52

12

0.99(0.964–1.017)

−0.01

0.469

 

 No

173

33

0.98(0.969–0.993)

−0.02

< 0.001

 

Malaria

0.175

 Yes

24

7

0.92(0.112–7.589)

−0.08

0.939

 

 No

187

38

0.98(0.967–0.990)

−0.02

< 0.001

 

HIV

0.021

 Yes

53

19

0.94(0.905–0.974)

−0.06

< 0.001

 

 No

171

26

0.99(0.979–1.002)

−0.01

0.098

 

Anemia

0.705

 Yes

104

31

0.98(0.921–0.994)

−0.02

0.004

 

 No

121

14

0.98(0.946–1.017)

−0.02

0.292

 

Blood transfusion

0.167

 Yes

37

9

0.88(0.225–3.416)

−0.132

0.849

 

 No

177

36

0.98(0.967–0.991)

−0.02

< 0.001

 
  1. This table shows that eGFR, after adjusting for covariates, was associated with in-hospital mortality in subgroup analyses. Significant interactions (P < 0.05) between eGFR and age, as well as eGFR and HIV status, influence mortality
  2. Fully adjusted for age(excluded in age subgroup comparison), gender(excluded in gender subgroup comparison), smoking cigarette(excluded in smoking subgroup comparison), Drinking(excluded in alcohol subgroup comparison), SBP, DBP, creatinine, alcohol withdraw(excluded in alcohol withdraw subgroup comparison), HTN(excluded in HTN subgroup comparison), DM(excluded in DM subgroup comparison), Malaria(excluded in malaria subgroup comparison), HIV(excluded in HIV subgroup comparison), and WBC
  3. Other abbreviation as in Table 1. Bold, statistically significant P value for interactions