Impact of estimated glomerular filtration rate (eGFR) on in-hospital mortality: an age- and HIV status-specific retrospective cohort study in Uganda

Table 3 Association of eGFR level and risk of in-hospital mortality

eGFR/ML/min/1.73 m² Quartile (Q) groups	Model^a			Model 2^b			Model 3^c
eGFR/ML/min/1.73 m² Quartile (Q) groups	HR(95%Cl)	P value	β	HR (95%Cl)	P value	β	HR (95%Cl)	P value	β
[≥ 120]	Reference = 1			Reference = 1			Reference = 1
[99.0–120]	0.88(0.244–3.164)	0.842	−0.13	0.87(0.240–3.137)	0.830	−0.14	1.08(0.276–4.226)	0.912	+ 0.08
[66.8–99.0]	3.09(1.099–8.715)	0.033	+ 1.13	3.06(1.08–8.658)	0.035	+ 1.12	4.079(1.284–12.954)	0.017	+ 1.41
[< 66.8]	3.55(1.363–9.228)	0.009	+ 1.27	3.56(1.368–9.260)	0.009	+ 1.27	4.08(1.284–12.954)	0.037	+ 1.25
Per-SD elevation 0.48.60/eGFR/ML/min/1	0.496(0.363–0.679)	< 0.001	−0.70	0.52(0.376–0.727)	< 0.001	−0.65	0.46(0.282–0.759)	0.002	−0.77

This table shows that dropping eGFR level, after adjusting for covariates, was independently associated with in-hospital mortality. These findings highlight eGFR as a critical indicator of patient outcomes, emphasizing the need for early kidney function assessment in clinical decision-making. HR indicates, hazard ratio; β, Beta coefficient; CI, confidence interval
Other abbreviation as in Table 1. Bold, statistically significant. Per-SD elevation, implies Per standard deviation (SD) elevation refers to the increase in the variable by one standard deviation, which is used for clinical applicability
^aAdjusted for age and gender
^bAdjusted for age, gender, smoking, and drinking
^cAdjusted for age, gender, smoking cigarette, drinking, SBP, DBP, creatinine, alcohol withdraw, HTN, DM, Malaria, HIV, and WBC

ISSN: 1471-2369