Table 1 Primary and secondary renal diseases managed with TPE

Recurrent Focal segmental glomerulosclerosis (FSGS)

Anti-GBM, Goodpasture Syndrome with Dialysis Independence or Diffuse Alveolar Hemorrhage

Kidney transplant

 ● ABO compatible

  ○ Antibody-mediated rejection (AMR)

  ○ Desensitization, living donor

 ● ABO incompatible

  ○ Desensitization, living donor

Thrombotic microangiopathy

 ● TTP

 ● Complement-mediated (Factor H autoantibody)

 ● Secondary to Ticlopidine

Catastrophic antiphospholipid syndrome (CAPS)

I

Amyloidosis, systemic, dialysis-related

Myeloma cast nephropathy

Systemic lupus erythematosus (severe)

Kidney transplant

 ● ABO incompatible (Antibody-mediated rejection)

Graft-versus-host disease

Cryoglobulinemia

II

Anti- GBM, Goodpasture Syndrome (Dialysis-dependence, no diffuse alveolar hemorrhage)

Steroid-Resistant FSGS in Native Kidney

Thrombotic Microangiopathy

 ● Coagulation-mediated

 ● Complement- mediated (gene mutation)

 ● Secondary to Clopidogrel

 ● Pregnancy-associated

  ○ Severe or extremely preterm preeclampsia

 ● Infection-associated

  ○ STEC^a or post-transplant HUS^b

 ● Transplantation-associated

ANCA^c-associated vasculitis

MPA^d, GPA^e, or EGPA^f

IgA nephropathy (crescentic, chronic progressive)

IgA vasculitis (Crescentic RPGN^g or severe extrarenal manifestations)

Nephrogenic systemic fibrosis

Medication overdose

III

Thrombotic Microangiopathy Secondary to Gemcitabine or Quinine

IV