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Table 3 Multivariate Survival Analysis on factors affecting the risk of ESKD or death

From: Lifetime progression of IgA nephropathy: a retrospective cohort study with extended long-term follow-up

Variable

HR

95% CI

p-value

Gender (male)

1.23

0.77–1.97

0.395

Age at diagnosis (years)

1.02

1.00–1.03

0.043

CKD stage at diagnosis (G2 compared to G1)

2.40

1.10–5.23

0.028

CKD stage at diagnosis (G3a compared to G1)

4.64

1.87–11.50

 < 0.001

CKD stage at diagnosis (G3b compared to G1)

8.49

3.56–20.25

 < 0.001

CKD stage at diagnosis (G4 compared to G1)

13.72

5.57–33.79

 < 0.001

CKD stage at diagnosis (G5 compared to G1)

27.90

6.42–121.22

 < 0.001

Proteinuria at diagnosis (g/24 h)

1.17

1.08–1.27

 < 0.001

Hematuria at diagnosis (yes)

1.05

0.38–2.93

0.920

Systolic blood pressure at diagnosis (mm Hg)

1.01

0.99–1.02

0.279

Diastolic blood pressure at diagnosis (mm Hg)

0.98

0.95–1.00

0.084

Use of RAAS inhibitor during follow-up (yes)

0.69

0.43–1.12

0.138

Use of immunosuppression during follow-up (yes)

1.28

0.77–2.12

0.335

  1. ESKD End-stage kidney disease. CKD Chronic kidney disease. RAAS Renin–angiotensin–aldosterone system. HR Hazard ratio. CI Confidence interval