Table 7 Safety endpoints
Parameter | All n = 15 | CVVH n = 5 | CVVHD-HCO n = 5 | CVVHD-CS n = 5 | p |
|---|---|---|---|---|---|
ICU stay (d) | 10 [4; 31] | 12 [5; 51] | 10 [1; 29] | 8 [6; 21] | 0.689 |
ICU mortality n, (%) | 9/15 (60) | 3/5 (60) | 3/5 (60) | 3/5 (60) | 1.000 |
hospital mortality n, (%) | 11/15 (73) | 4/5 (80) | 4/5 (80) | 3/5 (60) | 0.711 |
28d mortality n, (%) | 8/15 (53) | 2/5 (40) | 3/5 (60) | 3/5 (60) | 0.765 |
90d mortality n, (%) | 11/15 (73) | 4/5 (80) | 4/5 (80) | 3/5 (60) | 0.711 |
SAE | |||||
Treatment associated life-threatening complications n, (%) | 0/15 (0) | ||||
Dead of any cause during intervention n, (%) | 2/15 (13) | 0/5 (0) | 2/5 (40)a | 0/5 (0) | 0.099 |
AE | |||||
Hypocalcaemia n, (%) | 1/15 (7) | 0/5 (0) | 0/5 (0) | 1/5 (20) | 0.343 |
Metabolic alkalosis n, (%) | 0/15 (0) | ||||
Citrate accumulation n, (%) | 1/15 (7) | 0/5 (0) | 1/5 (20) | 0/5 (0) | 0.343 |
Bleeding with transfusion n, (%) | 0/15 (0) | ||||
Bleeding without transfusion n, (%) | 2/15 (13) | 2/5 (40) | 0/5 (0) | 0/5 (0) | 0.099 |
Clotting of extracorporeal circuit n, (%) | 2/15 (13) | 2/5 (40)b | 0/5 (0) | 0/5 (0) | 0.099 |
HIT n, (%) | 0/15 (0) | ||||
Dysfunction of dialysis catheter n, (%) | 2/15 (13) | 1/5 (20) | 1/5 (20) | 0/5 (0) | 0.562 |