Fig. 2

Association of HD modality and COVID-19 infection with all-cause mortality in yearly-cohort analysis. ^aHR (95% CI) for all-cause mortality calculated by Cox regression models, with dialysis modality and COVID-19 status as time-dependent variables, and adjusted for age, gender, ethnicity, tobacco use, renal etiology, comorbidities at yearly index date (including diabetes, cardiovascular disease, infectious disease, respiratory disease, digestive disease, genitourinary disease, and malignant disease), dialysis vintage at yearly index date, vascular access (frequency of 75% over the 6 months prior to yearly index date used to define type of vascular access, if not available at yearly index date), and average of systolic blood pressure over the 6 months prior to yearly index date, if not available at yearly index date. ^bHR (95% CI) for all-cause mortality calculated by Cox regression models, with dialysis modality and COVID-19 status as time-dependent variables, and adjusted for age, gender, ethnicity, tobacco use, renal etiology, comorbidities at yearly index date (including diabetes, cardiovascular disease, infectious disease, respiratory disease, digestive disease, genitourinary disease, and malignant disease), dialysis vintage at yearly index date, vascular access (frequency of 75% over the 6 months prior to yearly index date used to define type of vascular access, if not available at yearly index date), average of systolic blood pressure over the 6 months prior to yearly index date (if not available at yearly index date), and parameters calculated as the average values over the 6 months prior to yearly index date (if not available at yearly index date), including IDWG, treatment frequency, duration, blood flow rate, OCM Kt/V, overhydration, albumin, sodium, calcium, iPTH, hemoglobin, platelets, and leukocytes. HR, hazard ratio; CI, confidence interval; COVID-19, coronavirus disease 2019; HD, hemodialysis; IDWG, interdialytic weight gain; OCM, online clearance monitoring; OCM, online clearance monitoring; iPTH, intact parathyroid hormone