Fig. 1

(A) Systolic blood pressure (SBP), *P < 0.05 and ***P < 0.001 versus regimen-matched group. ###P < 0.001 vs. age-matched AL group. (B) diastolic blood pressure (DBP), *P < 0.05 and ***P < 0.001 versus regimen-matched group. #P < 0.05 vs. age-matched AL group and ###P < 0.001 vs. age-matched AL, FW group. (C) the mean arterial pressure (MAP) in different animal groups. * P < 0. 05 vs. regimen-matched young group, ***P < 0.001 vs. regimen-matched young and middle-aged group. ###P < 0.001 vs. age-matched AL group. (D) The plasma levels of Ang II in the rats. Values were measured using a rat Elisa kit. Data are represented as mean ± SEM, analysis was performed by one way ANOVA, 6 animals per group. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. regimen-matched young group. ##P < 0.01 and ###P < 0.001 vs. age-matched AL group. The measurements were from AL, ad libitum regimen; FW, fed ad libitum and fasted 1 day per week; EOD, fed ad libitum and fasted every other day