Fanconi syndrome with acute proximal tubular injury induced by a dietary supplement containing beni-koji: a case series report

Table 2 Reported cases of dietary supplement-induced Fanconi syndrome

Age (years)/sex	Underlying condition	Duration of supplement intake	Urine protein	DLST	Kidney biopsy	Steroid therapy	Full recovery of kidney function	Reference
73/F	Dyslipidemia	8 months	2.47 g/g creatinine	NA	ATIN	Yes	No	Murata et al. (2024) [10]
53/F	Dyslipidemia	8 months	4.25 g/g creatinine	NA	ATIN	Yes	No	Murata et al. (2024) [10]
55/F	Dyslipidemia	9 months	0.65 g/g creatinine	+	ATIN	Yes	No	Murata et al. (2024) [10]
66/F	Hashimoto’s disease	14 months	1.04 g/g creatinine	NA	MGA ATI	No	No	Takeuchi et al. (2024) [11]
54/M	Dyslipidemia, constipation	24 months	0.25 g/g creatinine	NA	Normal glomeruli ATI	No	No	Takeuchi et al. (2024) [11]
62/M	Reflux esophagitis	NA	1.63 g/day	NA	MGA ATI	No	No	Oda et al. (2024) [12]
58/F	Dyslipidemia	6 weeks	1.06 g/day	NA	Normal glomeruli ATIN	Yes	Yes	Maiguma et al. (2024) [13]
47/F	Dyslipidemia	7 months	1.38 g/day	NA	ATIN	Yes	No	Miyazaki et al. (2024) [14]
49/F	No	2 weeks	0.70 g/g creatinine	NA	Normal glomeruli ATIN	Yes	No	Chikasue et al. (2024) [15]
55/M	Intestinal obstruction	6 months	7.1 g/g creatinine	NA	No	No	No	Chikasue et al. (2024) [15]
60/F	No	7 months	2.87 g/g creatinine	NA	No	No	No	Chikasue et al. (2024) [15]
49/F	Dyslipidemia, pollinosis	1.5 years	0.86 g/day	+	Normal glomeruli ATI Megalin positive in injured tubular epithelium	No	Yes	Present case 1
68/F	Dyslipidemia	7 months	1.53 g/day	NA	Normal glomeruli ATI Megalin positive in injured tubular epithelium	No	No	Present case 2

Abbreviations: ATI acute tubular injury, ATIN acute tubulointerstitial nephritis, DLST drug-induced lymphocyte stimulation test, MGA minor glomerular abnormality, NA not applicable

ISSN: 1471-2369