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Table 2 Characteristics of individuals who died of COVID-19 related infection

From: Eight-fold increased COVID-19 mortality in autosomal dominant tubulointerstitial kidney disease due to MUC1 mutations: an observational study

Characteristic

ADTKD-MUC1

ADTKD-UMOD

P-value

Individuals (n)

19

3

 

Gender (n male (%))

11 (58%)

2 (67%)

0.89

Age, years (mean ± sd (median))

56.49 ± 8.45 (57.62)

71.44 ± 7.25 (74.80)

0.0002

Age > 60 years (n (%))

7 (37%)

3 (100%)

< 0.0001b

Body mass index, kg/m2 (mean ± sd (median))

30.78 ± 6.46 (30.74)

25.56 ± 2.02 (25.11)

0.02

Kidney transplanted (n (%))

16 (84%)

3 (100%)

0.46b

Pre-kidney failure (n (%))

2 (11%)

0

0.01b

No vaccination (n (percent of those reporting vaccination status)

11/16 (69%)

1 (33%)

0.23

Heart failure

0/18

0/3

---

Chronic obstructive pulmonary disease or asthma

1/18

0/3

0.14b

Diabetes mellitus

4/18

0/3

0.14b

Active malignancy

0/18

0/3

---

Past malignancyc

3/18

1/3

0.15b

Average length of hospital stay (mean ± sd (median))

18.67 ± 10.80 (21)

12 ± 5 (12)

0.15

Required mechanical ventilation

18/18 (100%)

2 (67%)

0.01b

Years of kidney failurea (mean ± sd (median))

12.86 ± 10.84 (9)

21.93 ± 14.96 (13.76)

0.45

> 10 years kidney failurea

9/17 (53%)

3 (100%)

0.003b

  1. aYears of kidney failure are years from start of kidney failure until contracting COVID-19
  2. bP-values calculated using permutation test
  3. CPast malignancies included Burkitts lymphoma, renal low grade papillary carcinoma, and cervical cancer in ADTKD-MUC1 and breast cancer in ADTKD-UMOD