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Table 5 Secondary analysis on main outcomes at 6 months

From: Evaluation of effect of cooled haemodialysis on cognition in patients with end-stage kidney disease (ECHECKED) feasibility randomised controlled trial results

 

Standard

Low

Difference in change (p =)

MOCA

N

17

18

 

Baseline

22.0 (17.0–25.0)

23.0 (17.8–26.0)

 

6 months

24.0 (16.0–25.5)

22.0 (18.0–26.0)

0.241

Change from baseline, p

0.0 (-2.0–2.5) p = 0.697

0.0 (-2.0 − 1.3) p = 0.588

 

HADS Depression

N

16

18

 

Baseline

6.0 (3.3–9.0)

4.0 (2.8–7.0)

 

6 months

3.0 (1.0–7.0)

3.5 (0.8–7.3)

< 0.001

Change from baseline, p

-1.0 (-2.8–0.8) p = 0.007

0.5 (-0.3–2.0) p = 0.449

 

HADS Anxiety

N

16

18

 

Baseline

3.0 (0.3–8.5)

2.0 (1.0–4.3)

 

6 months

5.0 (3.3–10.8)

4.5 (2.8–6.0)

0.774

Change from baseline, p

0.5 (-1.8–2.8) p = 0.078

0.5 (-2.0–2.0) p = 0.017

 

AQOL

N

16

18

 

Baseline

48.5 (10.2)

46.2 (8.7)

 

6 months

51.1 (10.0)

45.6 (13.2)

0.184

Change from baseline, p

2.6 (5.1) p = 0.063

-0.7 (9.2) p = 0.763

 

HD Recovery time

N

15

16

 

Baseline (hours)

4 (2–12)

3 (1–12)

 

6 months (hours)

6 (2–12)

4 (0–4)

0.821

Change from baseline (hours), p

0 (-4–3) p = 1.000

0 (-12–2) p = 0.334

 
  1. Data presented as Median (IQR); Mean (SD)
  2. MoCA – Montreal Cognitive Assessment tool, CAM – Confusion Assessment Method, QoL – quality of life, ADL – activities of daily living, HADS – Hospital Anxiety and Depression Scale, HD - haemodialysis