Table 5 Univariate logistic regression analysis for osteoporosis in premenopausal and postmenopausal patients with LN
Parameters | All patients Odds Ratio (95% CI) | Premenopausal patients Odds Ratio (95% CI) | Postmenopausal patients Odds Ratio (95% CI) |
|---|---|---|---|
Age (per year) | 1.041 (1.010, 1.072) | 1.039 (0.981, 1.100) | 0.997 (0.942, 1.055) |
Disease duration (per year) | 1.017 (0.958, 1.079) | 1.085 (0.959, 1.226) | 0.975 (0.906, 1.048) |
Age at diagnosis of LN (per year) | 1.033 (1.005, 1.061) | 1.024 (0.965, 1.088) | 1.010 (0.967, 1.054) |
Age at menopause (per year) | 0.878 (0.777, 0.992) | - | 0.878 (0.777, 0.992) |
Menopause duration (per year) | 1.081 (0.993, 1.176) | - | 1.081 (0.993, 1.176) |
SLEDAI score (per score) | 1.022 (0.962, 1.085) | 0.985 (0.900, 1.007) | 1.073 (0.973, 1.184) |
Weight (per kg) | 0.942 (0.901, 0.984) | 0.982 (0.901, 1.069) | 0.887 (0.830, 0.947) |
Height (per cm) | 0.883 (0.822, 0.948) | 0.882 (0.786, 0.989) | 0.835 (0.743, 0.939) |
Body mass index (per kg/m2) | 0.942 (0.846, 1.049) | 1.124 (0.912, 1.386) | 0.768 (0.649, 0.909) |
Proteinuria (with vs. without) | 1.082 (0.533, 2.195) | 0.517 (0.143, 1.870) | 1.361 (0.520, 3.566) |
Serum creatinine (per µmol/L) | 1.005 (0.993, 1.017) | 1.009 (0.977, 1.042) | 1.002 (0.990, 1.014) |
Blood urea nitrogen (per mmol/L) | 1.151 (0.995, 1.331) | 1.118 (0.865, 1.443) | 1.086 (0.915, 1.290) |
Uric acid (per µmol/L) | 1.001 (0.997, 1.004) | 1.001 (0.995, 1.008) | 0.999 (0.995, 1.004) |
Serum correction calcium (per mmol/L) | 2.528 (0.138, 46.323) | 0.352 (0.005, 26.116) | 3.539 (0.042, 299.305) |
Duration of use corticosteroids (per year) | 1.016 (0.956, 1.080) | 1.051 (0.935, 1.183) | 0.981 (0.909, 1.059) |
Corticosteroids max dosage (per mg/day) | 0.998 (0.989, 1.006) | 0.970 (0.936, 1.006) | 0.997 (0.987, 1.006) |
Immunosuppressant drugs (with vs. without) | 1.310 (0.581, 2.950) | 1.935 (0.474, 7.907) | 0.809 (0.261, 2.504) |
Antimalarial (with vs. without) | 1.905 (0.902, 4.029) | 1.407 (0.414, 4.784) | 2.206 (0.804, 6.056) |
Calcineurin inhibitors (with vs. without) | 0.957 (0.380, 2.406) | 0.795 (0.189, 3.341) | 2.000 (0.456, 8.772) |
Calcium supplements (with vs. without) | 1.193 (0.415, 3.431) | 1.026 (0.184, 5.718) | 1.611 (0.352, 7.364) |
α calcitriol supplements (with vs. without) | 0.845 (0.235, 3.046) | 0.793 (0.137, 4.582) | 0.909 (0.120, 6.862) |
Bisphosphonates (with vs. without) | 0.301 (0.145, 0.627) | 0.556 (0.154, 2.002) | 0.269 (0.096, 0.755) |