Prevalence and risk factors of osteoporosis in lupus nephritis patients in China: a cross-sectional study

Hong, Yu; Yang, Yi; Yao, Ying

doi:10.1186/s12882-024-03882-7

BMC Nephrology

Table 4 Multivariate linear regression analysis for BMD in premenopausal and postmenopausal patients with LN

From: Prevalence and risk factors of osteoporosis in lupus nephritis patients in China: a cross-sectional study

Parameters	lumbar spine		total hip		femoral neck
Parameters	β (95% CI)	P	β (95% CI)	P	β (95% CI)	P
All patients
Age (year)	0.005 (-0.003, 0.013)	0.325	0.004 (-0.003, 0.010)	0.287	0.002 (-0.004, 0.008)	0.546
Disease duration (year)	-0.016 (-0.029, -0.003)	0.014^*	-0.013 (-0.024, -0.002)	0.023^*	-0.013 (-0.023, -0.002)	0.017^*
Menopause duration (year)	-0.012 (-0.022, -0.003)	0.013^*	-0.011 (-0.020, -0.003)	0.009^**	-0.009 (-0.017, -0.001)	0.024^*
Body mass index (kg/m²)	0.024 (0.013, 0.034)	< 0.0001^***	0.025 (0.015, 0.034)	< 0.0001^***	0.026 (0.017, 0.035)	< 0.0001^***
Serum creatinine (µmol/L)	0.000 (0.000, 0.001)	0.311	0.000 (-0.001, 0.001)	0.652	0.000 (0.000, 0.001)	0.429
Duration of use glucocorticoids (year)	0.012 (-0.001, 0.025)	0.064	0.008 (-0.003, 0.019)	0.140	0.009 (-0.001, 0.019)	0.091
Premenopausal patients
Age (year)	0.003 (-0.002, 0.007)	0.200	0.000 (-0.003, 0.004)	0.945	-0.001 (-0.004, 0.003)	0.764
Disease duration (year)	0.001 (-0.014, 0.015)	0.923	-0.009 (-0.021, 0.002)	0.111	-0.003 (-0.014, 0.009)	0.639
Weight (per kg)	-0.001 (-0.007, 0.006)	0.870	0.003 (-0.002, 0.008)	0.253	0.002 (-0.003, 0.006)	0.527
Height (per cm)	0.012 (0.005, 0.018)	0.001^**	0.007 (0.002, 0.013)	0.010^*	0.005 (0.000, 0.011)	0.056
Serum creatinine (µmol/L)	0.001 (-0.002, 0.003)	0.546	-0.001 (-0.003, 0.001)	0.236	-0.001 (-0.003, 0.001)	0.368
Duration of use glucocorticoids (year)	-0.005 (-0.019, 0.009)	0.514	0.002 (-0.009, 0.013)	0.726	-0.002 (-0.013, 0.009)	0.637
Postmenopausal patients
Age (year)	0.005 (-0.003, 0.013)	0.234	0.004 (-0.003, 0.010)	0.287	0.002 (-0.004, 0.008)	0.546
Disease duration (year)	-0.016 (-0.029, -0.003)	0.014^*	-0.013 (-0.024, -0.002)	0.023^*	-0.013 (-0.023, -0.002)	0.017^*
Menopause duration (year)	-0.012 (-0.022, -0.003)	0.013^*	-0.011 (-0.020, -0.003)	0.009^**	-0.009 (-0.017, -0.001)	0.024^*
Body mass index (kg/m²)	0.024 (0.013, 0.034)	< 0.0001^***	0.025 (0.015, 0.034)	< 0.0001^***	0.026 (0.017, 0.035)	< 0.0001^***
Serum creatinine (µmol/L)	0.000 (0.000, 0.001)	0.311	0.000 (-0.001, 0.001)	0.652	0.000 (0.000, 0.001)	0.429
Duration of use glucocorticoids (year)	0.012 (-0.001, 0.025)	0.064	0.008 (-0.003, 0.019)	0.140	0.009 (-0.001, 0.019)	0.091

BMD, bone mineral density; LN, lupus nephritis; 95% CI, 95% confidence interval
^*P < 0.05, ^**P < 0.01, ^***P < 0.001

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ISSN: 1471-2369

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