Fig. 1

Increase in Hb levels positively associates with changes in mean corpuscular volume (MCV) in patients receiving hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) but not in those receiving erythropoiesis-stimulating agents (ESA). (A) Changes in hemoglobin (Hb) concentrations before and after the treatment in patients receiving ESA (left) and HIF-PHIs (right). (B) Changes in MCV, mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) before and after the treatment in patients receiving ESA (left) and HIF-PHIs (right). (C) Association of changes in Hb levels (ΔHb) with changes in MCV (ΔMCV) before and after the treatment in patients receiving ESA. (D) Association of changes in Hb levels (ΔHb) with changes in MCV (ΔMCV) before and after the treatment in patients receiving HIF-PHIs. Data are expressed as mean ± SD