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Table 2 Patient-reported outcomes according to anaemia and iron deficiency

From: Associations of anaemia and iron deficiency with health-related quality of life in patients with chronic kidney disease stage G3b-5 in Japan: sub analysis of the Reach-J CKD cohort study

Patient-reported outcomes

All patients

Anaemia

Iron deficiency

  

Hb levels (g/dL)

TSAT < 20 (%)

TSAT ≥ 20 (%)

 < 10

10–12

 > 12

 

Ferritin < 100 (ng/mL)

 ≥ 100 (ng/mL)

  

More severe anaemia

Mild/moderate anaemia

No anaemia

p-value

Absolute Iron deficiency

Functional Iron deficiency

 

p-value

Number of patients

2,174

254

1,054

866

 

75

22

538

 

KDQOL-36 scores, mean ± SD

 Kidney disease subscales

Burden of kidney disease

65 ± 25

59 ± 28

62 ± 25

71 ± 24

 < 0.001

57 ± 28

68 ± 24

61 ± 24

0.222

Symptoms of kidney disease

88 ± 13

86 ± 14

87 ± 14

90 ± 13

 < 0.001

89 ± 15

92 ± 12

87 ± 14

0.167

Effects of kidney disease

86 ± 16

81 ± 19

84 ± 16

90 ± 12

 < 0.001

82 ± 17

85 ± 15

84 ± 16

0.688

MCS

49 ± 9

47 ± 9

48 ± 10

50 ± 9

 < 0.001

47 ± 12

50 ± 8

48 ± 9

0.516

PCS

47 ± 9

44 ± 10

46 ± 9

48 ± 8

 < 0.001

46 ± 10

48 ± 8

46 ± 9

0.685

 MCS and PCS subdomains

General health

45 ± 16

43 ± 16

44 ± 16

48 ± 16

 < 0.001

45 ± 15

49 ± 19

44 ± 15

0.390

Physical function

80 ± 29

70 ± 34

77 ± 30

86 ± 24

 < 0.001

74 ± 33

83 ± 29

79 ± 30

0.435

Physical role

63 ± 44

52 ± 46

59 ± 45

71 ± 41

 < 0.001

58 ± 45

58 ± 47

61 ± 44

0.854

Emotional role

68 ± 44

59 ± 45

65 ± 45

76 ± 40

 < 0.001

60 ± 45

76 ± 39

67 ± 43

0.277

Pain

79 ± 27

73 ± 28

76 ± 28

83 ± 24

 < 0.001

75 ± 31

83 ± 26

79 ± 27

0.537

Emotional well-being

70 ± 20

67 ± 18

68 ± 20

72 ± 20

 < 0.001

66 ± 26

72 ± 19

68 ± 19

0.563

Energy

48 ± 28

42 ± 28

45 ± 28

52 ± 27

 < 0.001

47 ± 31

53 ± 21

44 ± 28

0.261

Social function

82 ± 25

77 ± 28

80 ± 25

85 ± 23

 < 0.001

82 ± 25

79 ± 27

81 ± 25

0.860

Physical activity level, %

 Never active

14

19

14

12

0.075

13

30

13

0.278

 Low active

38

39

39

37

 

39

35

46

 

 Highly active

47

42

46

50

 

48

35

41

 

CES-D 10 score, mean ± SD

7 ± 5

8 ± 6

7 ± 5

6 ± 5

 < 0.001

7 ± 6

6 ± 5

7 ± 6

0.366

  1. Continuous variables were summarized as means with standard deviations (SD). For comparisons, means were analysed using Student's t-test or ANOVA. Categorical variables were reported as frequencies and percentages, and comparisons between groups were conducted using Fisher’s exact test
  2. Abbreviations: KDQOL-36 36-item Kidney Disease Quality of Life, MCS Mental component summary, PCS Physical component summary, CES-D Center for Epidemiologic Studies Depression Scale
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BMC Nephrology

ISSN: 1471-2369

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