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Table 3 The decline of estimated glomerular filtration rate over time in IgAN patients with stage 4 CKD stratified by glomerular C3 and C1q deposits

From: The prognostic role of activation of the complement pathways in the progression of advanced IgA nephropathy to end-stage renal disease

eGFR

Glomerular C3 deposits

Glomerular C1q deposits

≤ 2+

≥ 3+

P

negative

positive

P

Baseline

25.3 (22.3–27.1)

23.8 (20.7–26.4)

0.32

24.8 (20.7–26.3)

25.9 (20.4–28.9)

0.39

Final

22.5 (14.9–42.6)

15.2 (11.3–24.1)

0.02

20.7 (14.8–35.0)

10.3(8.3–12.4)

< 0.001

â–³eGFR/M

-0.1 (-0.5-1.2)

-0.4 (-1.0-0.7)

0.015

-0.1 (-0.6-0.9)

-0.6 (-1.4-0.5)

0.006

  1. IgAN, IgA nephropathy; eGFR, estimated glomerular filtration rate, ml/min/1.73m2; â–³eGFR/M: the mean change in eGFR per month over the follow-up time