From: Effects of immunosuppressive therapy on renal prognosis in primary membranous nephropathy
 | Low risk (N = 223) | Moderate risk (N = 212) | High risk (N = 324) | |||
---|---|---|---|---|---|---|
 | HR (95%CI) | P value | HR (95%CI) | P value | HR (95%CI) | P value |
Demographics | Â | Â | Â | Â | Â | Â |
 Age | 1.02 | 0.0879 | 1.01 | 0.355 | 1.03 | < 0.0001 |
 Gender | 0.70 | 0.1881 | 0.90 | 0.6994 | 1.17 | 0.3939 |
 BMI | 0.97 | 0.3506 | 0.94 | 0.1197 | 0.91 | 0.0002 |
 SBP | 1.02 | 0.0006 | 1.01 | 0.1391 | 1.01 | 0.0423 |
 DBP | 1.04 | < 0.0001 | 1.00 | 0.8466 | 1.01 | 0.3237 |
Comorbidities | Â | Â | Â | Â | Â | Â |
 Diabetes mellitus | 1.72 | 0.2481 | 0.49 | 0.3275 | 1.91 | 0.035 |
 Hypertension | 1.36 | 0.2769 | 0.64 | 0.0837 | 1.35 | 0.0857 |
Clinical symptom (%) | Â | Â | Â | Â | Â | Â |
 Nephrotic syndrome* | / | / | 0.72 | 0.1855 | 0.93 | 0.7776 |
Laboratory measurements | Â | Â | Â | Â | Â | Â |
 Alb | 0.92 | < 0.0001 | 0.97 | 0.1468 | 0.98 | 0.2994 |
 Total cholesterol | 1.19 | 0.0025 | 1.13 | 0.0302 | 1.04 | 0.2685 |
 eGFR | 0.99 | 0.2139 | 0.99 | 0.1096 | 0.99 | 0.0162 |
 Proteinuria | 1.00 | 0.0011 | 1.00 | 0.8112 | 1.00 | 0.6837 |
 PLA2R Ab | 1.00 | 0.4955 | 1.00 | 0.0059 | 1.00 | 0.2181 |
Comedication | Â | Â | Â | Â | Â | Â |
 RASi | 0.79 | 0.4927 | 1.66 | 0.1828 | 1.53 | 0.0455 |
 Other hypotensive drugs | 4.85 | < 0.0001 | 1.36 | 0.2285 | 1.90 | 0.0004 |
 Antiplatelets drug | 1.21 | 0.4663 | 0.63 | 0.0673 | 0.54 | 0.0006 |
 Urate-lowering drugs | 1.09 | 0.8492 | 0.79 | 0.5755 | 0.55 | 0.1193 |
 Lipid regulating agents | 1.14 | 0.7168 | 0.73 | 0.293 | 0.93 | 0.7776 |
 Calcium supplements | 1.70 | 0.0452 | 1.05 | 0.8472 | 1.11 | 0.569 |
 Stomach protectants | 1.53 | 0.1275 | 0.34 | 0.0005 | 1.06 | 0.7466 |
 SGLT2i | 0.76 | 0.7904 | 0.00 | 0.9967 | 0.00 | 0.9932 |
Immunosuppressive therapy | 1.29 | 0.3536 | 0.50 | 0.0087 | 0.64 | 0.0116 |