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Table 5 Univariate cox analysis of renal composite outcome

From: Effects of immunosuppressive therapy on renal prognosis in primary membranous nephropathy

 

Total

Conservative group

Immunosuppressive Group

 

HR

p value

HR

p value

HR

p value

Age (years old)

1.02

0.0003

1.02

0.0151

1.02

0.0068

Male [n, (%)]

0.93

0.6262

0.72

0.119

1.26

0.3304

BMI (kg/m2)

0.94

0.0019

0.93

0.0178

0.94

0.0402

SBP (mmHg)

1.01

< 0.0001

1.01

0.0168

1.02

< 0.0001

DBP (mmHg)

1.02

0.0054

1.01

0.049

1.02

0.064

Diabetes mellitus

1.40

0.2798

1.31

0.517

1.52

0.365

Hypertension

1.17

0.3127

1.22

0.3292

1.09

0.7176

Nephrotic syndrome

1.36

0.0466

1.95

0.0017

0.88

0.5766

RASi

1.13

0.5464

0.94

0.8348

1.35

0.2942

Other hypotensive drugs

2.04

< 0.0001

1.86

0.0021

2.31

0.0004

Antiplatelets / Anticoagulant drug

0.70

0.0228

0.71

0.0994

0.69

0.1166

Urate-lowering drugs

0.68

0.2377

0.80

0.6005

0.54

0.2331

Lipid regulating agents

0.94

0.7803

1.23

0.4863

0.61

0.1236

Calcium supplements

1.43

0.0274

1.33

0.1599

1.63

0.072

Stomach protectants

1.03

0.87

0.79

0.417

1.28

0.3195

*SGLT2i

0.00

0.9919

0.00

0.9955

0.00

0.9959

WBC

1.00

0.9544

1.06

0.2222

1.03

0.3345

Hg

1.00

0.722

0.98

0.0019

0.99

0.0221

PLT

1.00

0.6224

1.00

0.1601

1.00

0.1835

HbA1c

1.09

0.5517

1.02

0.8925

1.05

0.6228

Alb

0.94

< 0.0001

0.92

< 0.0001

0.97

0.117

TC

1.13

< 0.0001

1.14

0.0001

1.13

0.0085

TG

1.05

0.1275

1.01

0.8145

1.11

0.0273

HDL-C

1.16

0.0736

1.03

0.8268

1.94

0.0011

LDL-C

1.12

0.0009

1.17

0.0003

1.05

0.3484

BUN

1.09

0.1345

1.08

0.1908

1.08

0.0472

URIC

1.00

0.0115

1.00

0.8895

1.00

0.0608

Cr

1.00

0.1275

1.00

0.0813

1.00

0.8377

eGFR

0.99

0.0036

0.99

0.021

0.99

0.0794

Proteinuria (mg/24-hour)

1.00

0.008

1.00

0.0059

1.00

0.3631

PLA2Rab

1.00

0.0002

1.00

0.0005

1.00

0.1701

  1. Abbreviations: BMI, body mass index; SBP, systolic blood pressure; DBP, diastolic blood pressure; RASi, renin-angiotensin-system inhibitors; SGLT2i, sodium-glucose cotransporter 2 inhibitors; WBC, white blood cells; Hg, hemoglobulin; PLT, platelets; HbA1c, hemoglobin A1c; Alb, albumin; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BUN, blood urea nitrogen; Cr, serum creatinine; eGFR, estimated glomerular filtration rate calculated by EPI formula; PLA2Rab, antibody titers of M-type phospholipase A2 receptor
  2. *SGLT2i: Very few individuals utilize SGLT2i. For reference only