Fig. 3

Efficacy of VLPD + KA on rate of decline in creatinine clearance in patients with slowly progressive CKD. The slope of creatinine clearance vs. time was −0.09 ml/min/month in patients prescribed 0.3 g/kg/day mixed protein supplemented with ketoanalogues (treatment group) while it was −0.3 in the patients allowed to continue regular diet (control group). One can notice that in the treatment group there was an initial rapid drop in creatinine clearance (possibly hemodynamically mediated). Thereafter, creatinine clearance stabilized. On the other hand, there was a progressive decline in creatinine clearance in the control group